Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients

Abstract Globally the number of patients on renal replacement therapy (RRT) is rising. Dyslipidemia is a potential modifiable cardiovascular risk factor, but its effect on risk of RRT or death in pre-dialysis patients is unclear. The aim of this study was to assess the association between dyslipidem...

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Autores principales:	Pauline W. M. Voskamp, Merel van Diepen, Friedo W. Dekker, Ellen K. Hoogeveen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0ec03a978324687b68ffcee54461d03
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spelling	oai:doaj.org-article:e0ec03a978324687b68ffcee54461d032021-12-02T15:08:54ZDyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients10.1038/s41598-018-20907-y2045-2322https://doaj.org/article/e0ec03a978324687b68ffcee54461d032018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20907-yhttps://doaj.org/toc/2045-2322Abstract Globally the number of patients on renal replacement therapy (RRT) is rising. Dyslipidemia is a potential modifiable cardiovascular risk factor, but its effect on risk of RRT or death in pre-dialysis patients is unclear. The aim of this study was to assess the association between dyslipidemia and risk of RRT or death among patients with CKD stage 4–5 receiving specialized pre-dialysis care, an often under represented group in clinical trials. Of the 502 incident pre-dialysis patients (>18 y) in the Dutch PREPARE-2 study, lipid levels were available in 284 patients and imputed for the other patients. During follow up 376 (75%) patients started RRT and 47 (9%) patients died. Dyslipidemia was defined as total cholesterol ≥5.00 mmol/L, LDL cholesterol ≥2.50 mmol/L, HDL cholesterol <1.00 mmol/L, HDL/LDL ratio <0.4, or triglycerides (TG) ≥2.25 mmol/L, and was present in 181 patients and absent in 93 patients. After multivariable adjustment Cox regression analyses showed a HR (95% CI) for the combined endpoint for dyslipidemia of 1.12 (0.85–1.47), and for high LDL of 1.20 (0.89–1.61). All other HRs were smaller. In conclusion, we did not find an association between dyslipidemia or the separate lipid levels and RRT or death in CKD patients on specialized pre-dialysis care.Pauline W. M. VoskampMerel van DiepenFriedo W. DekkerEllen K. HoogeveenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pauline W. M. Voskamp Merel van Diepen Friedo W. Dekker Ellen K. Hoogeveen Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
description	Abstract Globally the number of patients on renal replacement therapy (RRT) is rising. Dyslipidemia is a potential modifiable cardiovascular risk factor, but its effect on risk of RRT or death in pre-dialysis patients is unclear. The aim of this study was to assess the association between dyslipidemia and risk of RRT or death among patients with CKD stage 4–5 receiving specialized pre-dialysis care, an often under represented group in clinical trials. Of the 502 incident pre-dialysis patients (>18 y) in the Dutch PREPARE-2 study, lipid levels were available in 284 patients and imputed for the other patients. During follow up 376 (75%) patients started RRT and 47 (9%) patients died. Dyslipidemia was defined as total cholesterol ≥5.00 mmol/L, LDL cholesterol ≥2.50 mmol/L, HDL cholesterol <1.00 mmol/L, HDL/LDL ratio <0.4, or triglycerides (TG) ≥2.25 mmol/L, and was present in 181 patients and absent in 93 patients. After multivariable adjustment Cox regression analyses showed a HR (95% CI) for the combined endpoint for dyslipidemia of 1.12 (0.85–1.47), and for high LDL of 1.20 (0.89–1.61). All other HRs were smaller. In conclusion, we did not find an association between dyslipidemia or the separate lipid levels and RRT or death in CKD patients on specialized pre-dialysis care.
format	article
author	Pauline W. M. Voskamp Merel van Diepen Friedo W. Dekker Ellen K. Hoogeveen
author_facet	Pauline W. M. Voskamp Merel van Diepen Friedo W. Dekker Ellen K. Hoogeveen
author_sort	Pauline W. M. Voskamp
title	Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
title_short	Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
title_full	Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
title_fullStr	Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
title_full_unstemmed	Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
title_sort	dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e0ec03a978324687b68ffcee54461d03
work_keys_str_mv	AT paulinewmvoskamp dyslipidemiaandriskofrenalreplacementtherapyordeathinincidentpredialysispatients AT merelvandiepen dyslipidemiaandriskofrenalreplacementtherapyordeathinincidentpredialysispatients AT friedowdekker dyslipidemiaandriskofrenalreplacementtherapyordeathinincidentpredialysispatients AT ellenkhoogeveen dyslipidemiaandriskofrenalreplacementtherapyordeathinincidentpredialysispatients
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Dyslipidemia and risk of renal replacement therapy or death in incident pre-dialysis patients

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