Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis

Ramon Handerson Gomes Teles,1 Herick Fernando Moralles,2 Márcia Regina Cominetti1 1Department of Gerontology, 2Department of Production Engineering, Federal University of São Carlos, São Carlos, SP, Brazil Abstract: Nanotechnology has emerged as a promising tool in t...

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Autores principales:	Teles RHG, Moralles HF, Cominetti MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Oncology Breast cancer Nanotechnology Nanomedicine Bibliometric Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e0ed2f2c548f4061bc314b020332dffa
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spelling	oai:doaj.org-article:e0ed2f2c548f4061bc314b020332dffa2021-12-02T03:37:51ZGlobal trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis1178-2013https://doaj.org/article/e0ed2f2c548f4061bc314b020332dffa2018-04-01T00:00:00Zhttps://www.dovepress.com/global-trends-in-nanomedicine-research-on-triple-negative-breast-cance-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ramon Handerson Gomes Teles,1 Herick Fernando Moralles,2 Márcia Regina Cominetti1 1Department of Gerontology, 2Department of Production Engineering, Federal University of São Carlos, São Carlos, SP, Brazil Abstract: Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+). This cancer type has poor prognosis, high relapse rates, and no targeted therapies. Thus, this study aimed to investigate the trends of nanotechnology research in TNBC and compare the contribution of research from different regions, institutions, and authors. A search of the studies published between 2012 and 2017, related to nanotechnology and TNBC, with different keyword combinations, was performed in the Scopus database. The keywords found in this search were grouped into four clusters, in which “breast cancer” was the most mentioned (1,133 times) and the word “MCF-7 cell line” is one of the latest hotspots that appeared in the year 2016. A total of 1,932 articles, which were cited 26,450 times, were identified. The USA accounted for 28.36% of the articles and 27.61% of the citations; however, none of its centers appeared in the list of 10 most productive ones in terms of publications. The journals Biomaterials and International Journal of Nanomedicine had the highest number of publications. The USA and China had the highest number of articles produced and cited; however, the highest average citation per article was from Singapore. The studies focused on the research of antineoplastic agents in animal models and cell culture, and these were the most used topics in research with nanotechnology and TNBC. Keywords: oncology, breast cancer, nanotechnology, nanomedicine, bibliometricTeles RHGMoralles HFCominetti MRDove Medical PressarticleOncologyBreast cancerNanotechnologyNanomedicineBibliometricMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2321-2336 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oncology Breast cancer Nanotechnology Nanomedicine Bibliometric Medicine (General) R5-920
spellingShingle	Oncology Breast cancer Nanotechnology Nanomedicine Bibliometric Medicine (General) R5-920 Teles RHG Moralles HF Cominetti MR Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
description	Ramon Handerson Gomes Teles,1 Herick Fernando Moralles,2 Márcia Regina Cominetti1 1Department of Gerontology, 2Department of Production Engineering, Federal University of São Carlos, São Carlos, SP, Brazil Abstract: Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+). This cancer type has poor prognosis, high relapse rates, and no targeted therapies. Thus, this study aimed to investigate the trends of nanotechnology research in TNBC and compare the contribution of research from different regions, institutions, and authors. A search of the studies published between 2012 and 2017, related to nanotechnology and TNBC, with different keyword combinations, was performed in the Scopus database. The keywords found in this search were grouped into four clusters, in which “breast cancer” was the most mentioned (1,133 times) and the word “MCF-7 cell line” is one of the latest hotspots that appeared in the year 2016. A total of 1,932 articles, which were cited 26,450 times, were identified. The USA accounted for 28.36% of the articles and 27.61% of the citations; however, none of its centers appeared in the list of 10 most productive ones in terms of publications. The journals Biomaterials and International Journal of Nanomedicine had the highest number of publications. The USA and China had the highest number of articles produced and cited; however, the highest average citation per article was from Singapore. The studies focused on the research of antineoplastic agents in animal models and cell culture, and these were the most used topics in research with nanotechnology and TNBC. Keywords: oncology, breast cancer, nanotechnology, nanomedicine, bibliometric
format	article
author	Teles RHG Moralles HF Cominetti MR
author_facet	Teles RHG Moralles HF Cominetti MR
author_sort	Teles RHG
title	Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
title_short	Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
title_full	Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
title_fullStr	Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
title_full_unstemmed	Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
title_sort	global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e0ed2f2c548f4061bc314b020332dffa
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_version_	1718401704265777152

Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis

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