FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response a...

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Autores principales:	Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Maha Said, Viviana Barra, Viola Nähse, Silvia Ravera, Enrico Cappelli, Valeria Naim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0f19b4840814983bdab55f7127e98cd
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spelling	oai:doaj.org-article:e0f19b4840814983bdab55f7127e98cd2021-12-02T14:16:33ZFANCD2 modulates the mitochondrial stress response to prevent common fragile site instability10.1038/s42003-021-01647-82399-3642https://doaj.org/article/e0f19b4840814983bdab55f7127e98cd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01647-8https://doaj.org/toc/2399-3642Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response and transcription-associated replication stress. These findings suggest a FANCD2-mediated coordination of nuclear and mitochondrial responses to stress.Philippe FernandesBenoit MiottoClaude Saint-RufMaha SaidViviana BarraViola NähseSilvia RaveraEnrico CappelliValeria NaimNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Philippe Fernandes Benoit Miotto Claude Saint-Ruf Maha Said Viviana Barra Viola Nähse Silvia Ravera Enrico Cappelli Valeria Naim FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
description	Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response and transcription-associated replication stress. These findings suggest a FANCD2-mediated coordination of nuclear and mitochondrial responses to stress.
format	article
author	Philippe Fernandes Benoit Miotto Claude Saint-Ruf Maha Said Viviana Barra Viola Nähse Silvia Ravera Enrico Cappelli Valeria Naim
author_facet	Philippe Fernandes Benoit Miotto Claude Saint-Ruf Maha Said Viviana Barra Viola Nähse Silvia Ravera Enrico Cappelli Valeria Naim
author_sort	Philippe Fernandes
title	FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
title_short	FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
title_full	FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
title_fullStr	FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
title_full_unstemmed	FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
title_sort	fancd2 modulates the mitochondrial stress response to prevent common fragile site instability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0f19b4840814983bdab55f7127e98cd
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FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

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