Function of Centriolar Satellites and Regulation by Post-Translational Modifications

Centriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of these particles. Although initially linked to the...

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Autores principales:	Clotilde C. N. Renaud, Nicolas Bidère
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	centriolar satellites ubiquitin phosphorylation post-translational modification (PMT) centrosome primary cilia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e0f5844b2e154e45a2c2325b2c06c1fe
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id	oai:doaj.org-article:e0f5844b2e154e45a2c2325b2c06c1fe
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spelling	oai:doaj.org-article:e0f5844b2e154e45a2c2325b2c06c1fe2021-11-30T12:56:57ZFunction of Centriolar Satellites and Regulation by Post-Translational Modifications2296-634X10.3389/fcell.2021.780502https://doaj.org/article/e0f5844b2e154e45a2c2325b2c06c1fe2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780502/fullhttps://doaj.org/toc/2296-634XCentriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of these particles. Although initially linked to the homeostasis of centrosome and the formation of primary cilia, these composite and highly dynamic structures appear to participate in additional cellular processes, such as proteostasis, autophagy, and cellular stress. In this review, we first outline the main features and many roles of centriolar satellites. We then discuss how post-translational modifications, such as phosphorylation and ubiquitination, shape their composition and functions. This is of particular interest as interfering with these processes may provide ways to manipulate these structures.Clotilde C. N. RenaudNicolas BidèreFrontiers Media S.A.articlecentriolar satellitesubiquitinphosphorylationpost-translational modification (PMT)centrosomeprimary ciliaBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	centriolar satellites ubiquitin phosphorylation post-translational modification (PMT) centrosome primary cilia Biology (General) QH301-705.5
spellingShingle	centriolar satellites ubiquitin phosphorylation post-translational modification (PMT) centrosome primary cilia Biology (General) QH301-705.5 Clotilde C. N. Renaud Nicolas Bidère Function of Centriolar Satellites and Regulation by Post-Translational Modifications
description	Centriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of these particles. Although initially linked to the homeostasis of centrosome and the formation of primary cilia, these composite and highly dynamic structures appear to participate in additional cellular processes, such as proteostasis, autophagy, and cellular stress. In this review, we first outline the main features and many roles of centriolar satellites. We then discuss how post-translational modifications, such as phosphorylation and ubiquitination, shape their composition and functions. This is of particular interest as interfering with these processes may provide ways to manipulate these structures.
format	article
author	Clotilde C. N. Renaud Nicolas Bidère
author_facet	Clotilde C. N. Renaud Nicolas Bidère
author_sort	Clotilde C. N. Renaud
title	Function of Centriolar Satellites and Regulation by Post-Translational Modifications
title_short	Function of Centriolar Satellites and Regulation by Post-Translational Modifications
title_full	Function of Centriolar Satellites and Regulation by Post-Translational Modifications
title_fullStr	Function of Centriolar Satellites and Regulation by Post-Translational Modifications
title_full_unstemmed	Function of Centriolar Satellites and Regulation by Post-Translational Modifications
title_sort	function of centriolar satellites and regulation by post-translational modifications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e0f5844b2e154e45a2c2325b2c06c1fe
work_keys_str_mv	AT clotildecnrenaud functionofcentriolarsatellitesandregulationbyposttranslationalmodifications AT nicolasbidere functionofcentriolarsatellitesandregulationbyposttranslationalmodifications
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Function of Centriolar Satellites and Regulation by Post-Translational Modifications

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