Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia

Wondimagegn Wondimu,1 Lamessa Dube,2 Teshome Kabeta2 1Mizan Tepi University, College of Health Science, Department of Public Health, Mizan Aman, Ethiopia; 2Jimma University, Faculty of Public Health, Department of Epidemiology, Jimma, EthiopiaCorrespondence: Wondimagegn WondimuMizan Tepi University,...

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Autores principales:	Wondimu W, Dube L, Kabeta T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	tb/hiv co-infection survival rate mtuth Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e0fd1f58fdf346a6827c49b81bc1cb88
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spelling	oai:doaj.org-article:e0fd1f58fdf346a6827c49b81bc1cb882021-12-02T12:33:27ZFactors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia1179-1373https://doaj.org/article/e0fd1f58fdf346a6827c49b81bc1cb882020-04-01T00:00:00Zhttps://www.dovepress.com/factors-affecting-survival-rates-among-adult-tbhiv-co-infected-patient-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Wondimagegn Wondimu,1 Lamessa Dube,2 Teshome Kabeta2 1Mizan Tepi University, College of Health Science, Department of Public Health, Mizan Aman, Ethiopia; 2Jimma University, Faculty of Public Health, Department of Epidemiology, Jimma, EthiopiaCorrespondence: Wondimagegn WondimuMizan Tepi University, College of Health Science, Department of Public Health, Mizan Aman, EthiopiaTel +251 917255007Email wonde1983.ww@gmail.comBackground: Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection was responsible for approximately 300,000 deaths worldwide in 2017. Despite this burden of death, factors associated with the survival of TB-HIV co-infected patients were not adequately studied; and some of the existing evidences are inconsistent. This study was aimed to identify factors associated with survival rates of TB/HIV co-infected patients.Methods: The current study was a retrospective analysis of data extracted from 364 TB/HIV co-infected patients treated at Mizan Tepi University Teaching Hospital, Ethiopia, during the years 2007– 2017. Time to event was measured from the date of TB treatment initiation till death, loss to follow-up or completion of treatment. Since the event was death, patients lost from follow-up and those on follow-up were considered as censored. Using Cox-regression, the 95% CI of hazard ratio (HR) and P-value < 0.05 were used to identify the significant variables in multivariable analysis.Results: All the 364 patients were followed up for 1654 person-months. There were 83 (22.8%) deaths and the majority, 38 (45.8%), were occurring within the first two months of anti-TB treatment initiation. The overall incidence rate and median survival time were 5.02 per 100 person-months (95% CI: 4.05, 6.22) and 10 months, respectively. Not using CPT (adjusted hazard ratio [AHR] =1.72; P=0.023), bedridden functional status (AHR=2.55; P=0.007), not disclosing HIV status (AHR=4.03; P< 0.001) and CD4 < 200 cells/mm3 (AHR=6.05; P< 0.001) were factors associated with survival rates of TB/HIV co-infected patients.Conclusion: Our finding signals that care and attention should be given to the victims of these synergistic diseases. There is room to improve the survival of the patients if those with low CD4 count and bedridden functional status are closely monitored; and if CPT is promptly initiated with encouraging HIV status disclosure.Keywords: TB/HIV, co-infection, survival rate, MTUTHWondimu WDube LKabeta TDove Medical Pressarticletb/hivco-infectionsurvival ratemtuthImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 157-164 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tb/hiv co-infection survival rate mtuth Immunologic diseases. Allergy RC581-607
spellingShingle	tb/hiv co-infection survival rate mtuth Immunologic diseases. Allergy RC581-607 Wondimu W Dube L Kabeta T Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
description	Wondimagegn Wondimu,1 Lamessa Dube,2 Teshome Kabeta2 1Mizan Tepi University, College of Health Science, Department of Public Health, Mizan Aman, Ethiopia; 2Jimma University, Faculty of Public Health, Department of Epidemiology, Jimma, EthiopiaCorrespondence: Wondimagegn WondimuMizan Tepi University, College of Health Science, Department of Public Health, Mizan Aman, EthiopiaTel +251 917255007Email wonde1983.ww@gmail.comBackground: Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection was responsible for approximately 300,000 deaths worldwide in 2017. Despite this burden of death, factors associated with the survival of TB-HIV co-infected patients were not adequately studied; and some of the existing evidences are inconsistent. This study was aimed to identify factors associated with survival rates of TB/HIV co-infected patients.Methods: The current study was a retrospective analysis of data extracted from 364 TB/HIV co-infected patients treated at Mizan Tepi University Teaching Hospital, Ethiopia, during the years 2007– 2017. Time to event was measured from the date of TB treatment initiation till death, loss to follow-up or completion of treatment. Since the event was death, patients lost from follow-up and those on follow-up were considered as censored. Using Cox-regression, the 95% CI of hazard ratio (HR) and P-value < 0.05 were used to identify the significant variables in multivariable analysis.Results: All the 364 patients were followed up for 1654 person-months. There were 83 (22.8%) deaths and the majority, 38 (45.8%), were occurring within the first two months of anti-TB treatment initiation. The overall incidence rate and median survival time were 5.02 per 100 person-months (95% CI: 4.05, 6.22) and 10 months, respectively. Not using CPT (adjusted hazard ratio [AHR] =1.72; P=0.023), bedridden functional status (AHR=2.55; P=0.007), not disclosing HIV status (AHR=4.03; P< 0.001) and CD4 < 200 cells/mm3 (AHR=6.05; P< 0.001) were factors associated with survival rates of TB/HIV co-infected patients.Conclusion: Our finding signals that care and attention should be given to the victims of these synergistic diseases. There is room to improve the survival of the patients if those with low CD4 count and bedridden functional status are closely monitored; and if CPT is promptly initiated with encouraging HIV status disclosure.Keywords: TB/HIV, co-infection, survival rate, MTUTH
format	article
author	Wondimu W Dube L Kabeta T
author_facet	Wondimu W Dube L Kabeta T
author_sort	Wondimu W
title	Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
title_short	Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
title_full	Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
title_fullStr	Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
title_full_unstemmed	Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia
title_sort	factors affecting survival rates among adult tb/hiv co-infected patients in mizan tepi university teaching hospital, south west ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e0fd1f58fdf346a6827c49b81bc1cb88
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Factors Affecting Survival Rates Among Adult TB/HIV Co-Infected Patients in Mizan Tepi University Teaching Hospital, South West Ethiopia

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