A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States

Abstract Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding the epidemiology of pediatric COVID-19 infections. We sought to...

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Autores principales:	Vibhu Parcha, Katherine S. Booker, Rajat Kalra, Seth Kuranz, Lorenzo Berra, Garima Arora, Pankaj Arora
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0fe78e5a3c04756bfb34196bcff375c
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spelling	oai:doaj.org-article:e0fe78e5a3c04756bfb34196bcff375c2021-12-02T17:16:05ZA retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States10.1038/s41598-021-89553-12045-2322https://doaj.org/article/e0fe78e5a3c04756bfb34196bcff375c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89553-1https://doaj.org/toc/2045-2322Abstract Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding the epidemiology of pediatric COVID-19 infections. We sought to assess the clinical characteristics and outcomes in pediatric COVID-19 patients. We conducted a retrospective cross-sectional analysis of pediatric patients diagnosed with COVID-19 from healthcare organizations in the United States. The study outcomes (hospitalization, mechanical ventilation, critical care) were assessed using logistic regression. The subgroups of sex and race were compared after propensity score matching. Among 12,306 children with lab-confirmed COVID-19, 16.5% presented with respiratory symptoms (cough, dyspnea), 13.9% had gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain), 8.1% had dermatological symptoms (rash), 4.8% had neurological (headache), and 18.8% had other non-specific symptoms (fever, malaise, myalgia, arthralgia and disturbances of smell or taste). In the study cohort, the hospitalization frequency was 5.3%, with 17.6% needing critical care services and 4.1% requiring mechanical ventilation. Following propensity score matching, the risk of all outcomes was similar between males and females. Following propensity score matching, the risk of hospitalization was greater in non-Hispanic Black (RR 1.97 [95% CI 1.49–2.61]) and Hispanic children (RR 1.31 [95% CI 1.03–1.78]) compared with non-Hispanic Whites. In the pediatric population infected with COVID-19, a substantial proportion were hospitalized due to the illness and developed adverse clinical outcomes.Vibhu ParchaKatherine S. BookerRajat KalraSeth KuranzLorenzo BerraGarima AroraPankaj AroraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vibhu Parcha Katherine S. Booker Rajat Kalra Seth Kuranz Lorenzo Berra Garima Arora Pankaj Arora A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
description	Abstract Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding the epidemiology of pediatric COVID-19 infections. We sought to assess the clinical characteristics and outcomes in pediatric COVID-19 patients. We conducted a retrospective cross-sectional analysis of pediatric patients diagnosed with COVID-19 from healthcare organizations in the United States. The study outcomes (hospitalization, mechanical ventilation, critical care) were assessed using logistic regression. The subgroups of sex and race were compared after propensity score matching. Among 12,306 children with lab-confirmed COVID-19, 16.5% presented with respiratory symptoms (cough, dyspnea), 13.9% had gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain), 8.1% had dermatological symptoms (rash), 4.8% had neurological (headache), and 18.8% had other non-specific symptoms (fever, malaise, myalgia, arthralgia and disturbances of smell or taste). In the study cohort, the hospitalization frequency was 5.3%, with 17.6% needing critical care services and 4.1% requiring mechanical ventilation. Following propensity score matching, the risk of all outcomes was similar between males and females. Following propensity score matching, the risk of hospitalization was greater in non-Hispanic Black (RR 1.97 [95% CI 1.49–2.61]) and Hispanic children (RR 1.31 [95% CI 1.03–1.78]) compared with non-Hispanic Whites. In the pediatric population infected with COVID-19, a substantial proportion were hospitalized due to the illness and developed adverse clinical outcomes.
format	article
author	Vibhu Parcha Katherine S. Booker Rajat Kalra Seth Kuranz Lorenzo Berra Garima Arora Pankaj Arora
author_facet	Vibhu Parcha Katherine S. Booker Rajat Kalra Seth Kuranz Lorenzo Berra Garima Arora Pankaj Arora
author_sort	Vibhu Parcha
title	A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
title_short	A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
title_full	A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
title_fullStr	A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
title_full_unstemmed	A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States
title_sort	retrospective cohort study of 12,306 pediatric covid-19 patients in the united states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0fe78e5a3c04756bfb34196bcff375c
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A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States

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