Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan
Abstract Anal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were ob...
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Nature Portfolio
2021
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oai:doaj.org-article:e0ff6f63d3074abdbf266a71471dd46d2021-12-02T17:37:40ZAnal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan10.1038/s41598-021-98720-32045-2322https://doaj.org/article/e0ff6f63d3074abdbf266a71471dd46d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98720-3https://doaj.org/toc/2045-2322Abstract Anal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were obtained, and cytological results were examined. Hybrid capture-based methodology was used for hr-HPV genotyping. The exclusion criterion was a history of vaccination against HPV. 644 subjects participated, and the overall prevalence of hr-HPV was 59.7% (95% CI 54.7–62.3), HIV-infected had higher prevalence than HIV-uninfected (68.9% vs 40.6%) p < .001. Among hr-HPV-infected participants, 82.8% (312/377) were infected with at least one of 9 valent vaccine-covered hr-HPV genotypes. From regression analysis, detection of abnormal cytology correlated positively with HIV infection (OR 2.17 [95% CI 1.51–3.13]), number of hr-HPV genotypes infected (OR 1.83 [1.59–2.10]), history of STI (OR 1.58 [1.14–2.22]) and No. of lifetime sexual partners (OR 1.56 [1.10–2.21]), albeit multivariate analysis identified the number of detected hr-HPV genotypes (adjusted OR 1.78 [1.54–2.06]) as the independent risk factor for abnormal cytology. High rates of anal hr-HPV infection, especially 9-valent HPV vaccine-preventable hr-HPV were detected among our MSM participants in Japan. HPV vaccination should also be encouraged for MSM in Japan.Daisuke ShiojiriDaisuke MizushimaMisao TakanoKoji WatanabeNaokatsu AndoHaruka UemuraYasuaki YanagawaTakahiro AokiJunko TanumaKunihisa TsukadaKatsuji TeruyaYoshimi KikuchiHiroyuki GatanagaShinichi OkaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Daisuke Shiojiri Daisuke Mizushima Misao Takano Koji Watanabe Naokatsu Ando Haruka Uemura Yasuaki Yanagawa Takahiro Aoki Junko Tanuma Kunihisa Tsukada Katsuji Teruya Yoshimi Kikuchi Hiroyuki Gatanaga Shinichi Oka Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| description |
Abstract Anal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were obtained, and cytological results were examined. Hybrid capture-based methodology was used for hr-HPV genotyping. The exclusion criterion was a history of vaccination against HPV. 644 subjects participated, and the overall prevalence of hr-HPV was 59.7% (95% CI 54.7–62.3), HIV-infected had higher prevalence than HIV-uninfected (68.9% vs 40.6%) p < .001. Among hr-HPV-infected participants, 82.8% (312/377) were infected with at least one of 9 valent vaccine-covered hr-HPV genotypes. From regression analysis, detection of abnormal cytology correlated positively with HIV infection (OR 2.17 [95% CI 1.51–3.13]), number of hr-HPV genotypes infected (OR 1.83 [1.59–2.10]), history of STI (OR 1.58 [1.14–2.22]) and No. of lifetime sexual partners (OR 1.56 [1.10–2.21]), albeit multivariate analysis identified the number of detected hr-HPV genotypes (adjusted OR 1.78 [1.54–2.06]) as the independent risk factor for abnormal cytology. High rates of anal hr-HPV infection, especially 9-valent HPV vaccine-preventable hr-HPV were detected among our MSM participants in Japan. HPV vaccination should also be encouraged for MSM in Japan. |
| format |
article |
| author |
Daisuke Shiojiri Daisuke Mizushima Misao Takano Koji Watanabe Naokatsu Ando Haruka Uemura Yasuaki Yanagawa Takahiro Aoki Junko Tanuma Kunihisa Tsukada Katsuji Teruya Yoshimi Kikuchi Hiroyuki Gatanaga Shinichi Oka |
| author_facet |
Daisuke Shiojiri Daisuke Mizushima Misao Takano Koji Watanabe Naokatsu Ando Haruka Uemura Yasuaki Yanagawa Takahiro Aoki Junko Tanuma Kunihisa Tsukada Katsuji Teruya Yoshimi Kikuchi Hiroyuki Gatanaga Shinichi Oka |
| author_sort |
Daisuke Shiojiri |
| title |
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| title_short |
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| title_full |
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| title_fullStr |
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| title_full_unstemmed |
Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan |
| title_sort |
anal human papillomavirus infection and its relationship with abnormal anal cytology among msm with or without hiv infection in japan |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e0ff6f63d3074abdbf266a71471dd46d |
| work_keys_str_mv |
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| _version_ |
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