Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies

Abstract More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and evidence strength evaluation of published candida...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Junjun Wang, Qingyun Liu, Shuai Yuan, Weijia Xie, Yuan Liu, Ying Xiang, Na Wu, Long Wu, Xiangyu Ma, Tongjian Cai, Yao Zhang, Zhifu Sun, Yafei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1047c75ad264ccf92395be4cd382a72
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1047c75ad264ccf92395be4cd382a72
record_format	dspace
spelling	oai:doaj.org-article:e1047c75ad264ccf92395be4cd382a722021-12-02T12:32:16ZGenetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies10.1038/s41598-017-07737-02045-2322https://doaj.org/article/e1047c75ad264ccf92395be4cd382a722017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07737-0https://doaj.org/toc/2045-2322Abstract More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and evidence strength evaluation of published candidate-gene association studies in lung cancer up to November 1, 2015. The epidemiological credibility of cumulative evidence was assessed using the Venice criteria. A total of 1018 publications with 2910 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion. Main meta-analyses were performed on 246 variants in 138 different genes. Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence. No significant associations with lung cancer risk were found for other 150 variants in 98 genes; however, seven variants demonstrated strong cumulative evidence. Our findings provided the most updated summary of genetic risk effects on lung cancer and would help inform future research direction.Junjun WangQingyun LiuShuai YuanWeijia XieYuan LiuYing XiangNa WuLong WuXiangyu MaTongjian CaiYao ZhangZhifu SunYafei LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junjun Wang Qingyun Liu Shuai Yuan Weijia Xie Yuan Liu Ying Xiang Na Wu Long Wu Xiangyu Ma Tongjian Cai Yao Zhang Zhifu Sun Yafei Li Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
description	Abstract More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and evidence strength evaluation of published candidate-gene association studies in lung cancer up to November 1, 2015. The epidemiological credibility of cumulative evidence was assessed using the Venice criteria. A total of 1018 publications with 2910 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion. Main meta-analyses were performed on 246 variants in 138 different genes. Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence. No significant associations with lung cancer risk were found for other 150 variants in 98 genes; however, seven variants demonstrated strong cumulative evidence. Our findings provided the most updated summary of genetic risk effects on lung cancer and would help inform future research direction.
format	article
author	Junjun Wang Qingyun Liu Shuai Yuan Weijia Xie Yuan Liu Ying Xiang Na Wu Long Wu Xiangyu Ma Tongjian Cai Yao Zhang Zhifu Sun Yafei Li
author_facet	Junjun Wang Qingyun Liu Shuai Yuan Weijia Xie Yuan Liu Ying Xiang Na Wu Long Wu Xiangyu Ma Tongjian Cai Yao Zhang Zhifu Sun Yafei Li
author_sort	Junjun Wang
title	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
title_short	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
title_full	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
title_fullStr	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
title_full_unstemmed	Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
title_sort	genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e1047c75ad264ccf92395be4cd382a72
work_keys_str_mv	AT junjunwang geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT qingyunliu geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT shuaiyuan geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT weijiaxie geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT yuanliu geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT yingxiang geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT nawu geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT longwu geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT xiangyuma geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT tongjiancai geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT yaozhang geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT zhifusun geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies AT yafeili geneticpredispositiontolungcancercomprehensiveliteratureintegrationmetaanalysisandmultipleevidenceassessmentofcandidategeneassociationstudies
_version_	1718394127428616192

Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies

Ejemplares similares