The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients

Background: Cataract is one of the most common age-related vision deteriorations, leading to opacification of the lens and therefore visual impairment as well as blindness. Both cataract extraction and the implantation of blue light filtering lens are believed to improve not only vision but also ove...

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Autores principales:	Anna Maria Sobczak, Bartosz Bohaterewicz, Magdalena Fafrowicz, Aleksandra Domagalik, Ewa Beldzik, Halszka Oginska, Natalia Golonka, Marek Rekas, Dominik Bronicki, Bożena Romanowska-Dixon, Joanna Bolsega-Pacud, Waldemar Karwowski, Farzad V. Farahani, Tadeusz Marek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuroimaging fMRI graphs cataract blue light Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e105dbaa0b5e49bf9a970ee79464d58e
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spelling	oai:doaj.org-article:e105dbaa0b5e49bf9a970ee79464d58e2021-11-25T16:56:35ZThe Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients10.3390/brainsci111114002076-3425https://doaj.org/article/e105dbaa0b5e49bf9a970ee79464d58e2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1400https://doaj.org/toc/2076-3425Background: Cataract is one of the most common age-related vision deteriorations, leading to opacification of the lens and therefore visual impairment as well as blindness. Both cataract extraction and the implantation of blue light filtering lens are believed to improve not only vision but also overall functioning. Methods: Thirty-four cataract patients were subject to resting-state functional magnetic resonance imaging before and after cataract extraction and intraocular lens implantation (IOL). Global and local graph metrics were calculated in order to investigate the reorganization of functional network architecture associated with alterations in blue light transmittance. Psychomotor vigilance task (PVT) was conducted. Results: Graph theory-based analysis revealed decreased eigenvector centrality after the cataract extraction and IOL replacement in inferior occipital gyrus, superior parietal gyrus and many cerebellum regions as well as increased clustering coefficient in superior and inferior parietal gyrus, middle temporal gyrus and various cerebellum regions. PVT results revealed significant change between experimental sessions as patients responded faster after IOL replacement. Moreover, a few regions were correlated with the difference in blue light transmittance and the time reaction in PVT. Conclusion: Current study revealed substantial functional network architecture reorganization associated with cataract extraction and alteration in blue light transmittance.Anna Maria SobczakBartosz BohaterewiczMagdalena FafrowiczAleksandra DomagalikEwa BeldzikHalszka OginskaNatalia GolonkaMarek RekasDominik BronickiBożena Romanowska-DixonJoanna Bolsega-PacudWaldemar KarwowskiFarzad V. FarahaniTadeusz MarekMDPI AGarticleneuroimagingfMRIgraphscataractblue lightNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1400, p 1400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroimaging fMRI graphs cataract blue light Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neuroimaging fMRI graphs cataract blue light Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Anna Maria Sobczak Bartosz Bohaterewicz Magdalena Fafrowicz Aleksandra Domagalik Ewa Beldzik Halszka Oginska Natalia Golonka Marek Rekas Dominik Bronicki Bożena Romanowska-Dixon Joanna Bolsega-Pacud Waldemar Karwowski Farzad V. Farahani Tadeusz Marek The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
description	Background: Cataract is one of the most common age-related vision deteriorations, leading to opacification of the lens and therefore visual impairment as well as blindness. Both cataract extraction and the implantation of blue light filtering lens are believed to improve not only vision but also overall functioning. Methods: Thirty-four cataract patients were subject to resting-state functional magnetic resonance imaging before and after cataract extraction and intraocular lens implantation (IOL). Global and local graph metrics were calculated in order to investigate the reorganization of functional network architecture associated with alterations in blue light transmittance. Psychomotor vigilance task (PVT) was conducted. Results: Graph theory-based analysis revealed decreased eigenvector centrality after the cataract extraction and IOL replacement in inferior occipital gyrus, superior parietal gyrus and many cerebellum regions as well as increased clustering coefficient in superior and inferior parietal gyrus, middle temporal gyrus and various cerebellum regions. PVT results revealed significant change between experimental sessions as patients responded faster after IOL replacement. Moreover, a few regions were correlated with the difference in blue light transmittance and the time reaction in PVT. Conclusion: Current study revealed substantial functional network architecture reorganization associated with cataract extraction and alteration in blue light transmittance.
format	article
author	Anna Maria Sobczak Bartosz Bohaterewicz Magdalena Fafrowicz Aleksandra Domagalik Ewa Beldzik Halszka Oginska Natalia Golonka Marek Rekas Dominik Bronicki Bożena Romanowska-Dixon Joanna Bolsega-Pacud Waldemar Karwowski Farzad V. Farahani Tadeusz Marek
author_facet	Anna Maria Sobczak Bartosz Bohaterewicz Magdalena Fafrowicz Aleksandra Domagalik Ewa Beldzik Halszka Oginska Natalia Golonka Marek Rekas Dominik Bronicki Bożena Romanowska-Dixon Joanna Bolsega-Pacud Waldemar Karwowski Farzad V. Farahani Tadeusz Marek
author_sort	Anna Maria Sobczak
title	The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
title_short	The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
title_full	The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
title_fullStr	The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
title_full_unstemmed	The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients
title_sort	influence of intraocular lens implantation and alterations in blue light transmittance level on the brain functional network architecture reorganization in cataract patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e105dbaa0b5e49bf9a970ee79464d58e
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The Influence of Intraocular Lens Implantation and Alterations in Blue Light Transmittance Level on the Brain Functional Network Architecture Reorganization in Cataract Patients

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