An allosteric ligand-binding site in the extracellular cap of K2P channels

TREKs are members of the two-pore domain potassium (K2P) channels, being important clinical targets. Here the authors identify inhibitors of K2P that bind to an allosteric site located in their extracellular cap, suggesting that it might be a promising drug target for these channels.

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Autores principales:	Qichao Luo, Liping Chen, Xi Cheng, Yuqin Ma, Xiaona Li, Bing Zhang, Li Li, Shilei Zhang, Fei Guo, Yang Li, Huaiyu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e10847ccfd6b420b8772f417a958f875
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spelling	oai:doaj.org-article:e10847ccfd6b420b8772f417a958f8752021-12-02T15:38:51ZAn allosteric ligand-binding site in the extracellular cap of K2P channels10.1038/s41467-017-00499-32041-1723https://doaj.org/article/e10847ccfd6b420b8772f417a958f8752017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00499-3https://doaj.org/toc/2041-1723TREKs are members of the two-pore domain potassium (K2P) channels, being important clinical targets. Here the authors identify inhibitors of K2P that bind to an allosteric site located in their extracellular cap, suggesting that it might be a promising drug target for these channels.Qichao LuoLiping ChenXi ChengYuqin MaXiaona LiBing ZhangLi LiShilei ZhangFei GuoYang LiHuaiyu YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qichao Luo Liping Chen Xi Cheng Yuqin Ma Xiaona Li Bing Zhang Li Li Shilei Zhang Fei Guo Yang Li Huaiyu Yang An allosteric ligand-binding site in the extracellular cap of K2P channels
description	TREKs are members of the two-pore domain potassium (K2P) channels, being important clinical targets. Here the authors identify inhibitors of K2P that bind to an allosteric site located in their extracellular cap, suggesting that it might be a promising drug target for these channels.
format	article
author	Qichao Luo Liping Chen Xi Cheng Yuqin Ma Xiaona Li Bing Zhang Li Li Shilei Zhang Fei Guo Yang Li Huaiyu Yang
author_facet	Qichao Luo Liping Chen Xi Cheng Yuqin Ma Xiaona Li Bing Zhang Li Li Shilei Zhang Fei Guo Yang Li Huaiyu Yang
author_sort	Qichao Luo
title	An allosteric ligand-binding site in the extracellular cap of K2P channels
title_short	An allosteric ligand-binding site in the extracellular cap of K2P channels
title_full	An allosteric ligand-binding site in the extracellular cap of K2P channels
title_fullStr	An allosteric ligand-binding site in the extracellular cap of K2P channels
title_full_unstemmed	An allosteric ligand-binding site in the extracellular cap of K2P channels
title_sort	allosteric ligand-binding site in the extracellular cap of k2p channels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e10847ccfd6b420b8772f417a958f875
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An allosteric ligand-binding site in the extracellular cap of K2P channels

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