CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS

Abstract. The paper presents literature data and results of own studies on the Kaposi's sarcoma herpesvirus (KSHV) and its association with Kaposi's sarcoma (KS), the primary effusion lymphoma (PEL) and multicentric Kastleman disease (MCD). The obtained data show that all 3 main clinical f...

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Autores principales:	V. E. Gurtsevich, L. S. Yakovleva, S. A. Galetskiy, T. A. Afanasieva, N. B. Senjuta, V. N. Stepina, E. L. Kadyrova, D. A. Shirokov, M. M. Anokhina, T. T Kondratieva, N. N. Tupitsin, A. Zhessan
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	kaposi’s sarcoma herpesvirus kaposi’s sarcoma the primary effusion lymphoma multicentric kastleman disease diagnostics Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e1096cd94553435ab54e5ccf59b6ecf3
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spelling	oai:doaj.org-article:e1096cd94553435ab54e5ccf59b6ecf32021-11-22T07:09:45ZCLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS2220-76192313-739810.15789/2220-7619-2011-2-151-160https://doaj.org/article/e1096cd94553435ab54e5ccf59b6ecf32014-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/40https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The paper presents literature data and results of own studies on the Kaposi's sarcoma herpesvirus (KSHV) and its association with Kaposi's sarcoma (KS), the primary effusion lymphoma (PEL) and multicentric Kastleman disease (MCD). The obtained data show that all 3 main clinical forms of KS, diagnosed in Russia, are significantly associated with KSHV, though not always in 100% of cases. Distinct groups of persons with high prevalence of virus infection have been detected among patients with other forms of cancer and non-cancer diseases that may represent a risk factor for development of KS. It was found that the prostate, especially in patients with carcinoma of the prostate and KS could be an important localization of virus and intimate contact with these patients should be limited. For the first time in Russia HIV-negative case of PEL associated with KSHV had been diagnosed and studied in details. It was also demonstrated that isolates of KSHV, circulating in the country, belong to the two major genetic subgroups of the virus (A and C), a widely represented in the European countries and in the United States, which indicates a common origin of the virus in these countries. The current methodologies of KS’ treatment are also presented.V. E. GurtsevichL. S. YakovlevaS. A. GaletskiyT. A. AfanasievaN. B. SenjutaV. N. StepinaE. L. KadyrovaD. A. ShirokovM. M. AnokhinaT. T KondratievaN. N. TupitsinA. ZhessanSankt-Peterburg : NIIÈM imeni Pasteraarticlekaposi’s sarcoma herpesviruskaposi’s sarcomathe primary effusion lymphomamulticentric kastleman diseasediagnosticsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 2, Pp 151-160 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	kaposi’s sarcoma herpesvirus kaposi’s sarcoma the primary effusion lymphoma multicentric kastleman disease diagnostics Infectious and parasitic diseases RC109-216
spellingShingle	kaposi’s sarcoma herpesvirus kaposi’s sarcoma the primary effusion lymphoma multicentric kastleman disease diagnostics Infectious and parasitic diseases RC109-216 V. E. Gurtsevich L. S. Yakovleva S. A. Galetskiy T. A. Afanasieva N. B. Senjuta V. N. Stepina E. L. Kadyrova D. A. Shirokov M. M. Anokhina T. T Kondratieva N. N. Tupitsin A. Zhessan CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
description	Abstract. The paper presents literature data and results of own studies on the Kaposi's sarcoma herpesvirus (KSHV) and its association with Kaposi's sarcoma (KS), the primary effusion lymphoma (PEL) and multicentric Kastleman disease (MCD). The obtained data show that all 3 main clinical forms of KS, diagnosed in Russia, are significantly associated with KSHV, though not always in 100% of cases. Distinct groups of persons with high prevalence of virus infection have been detected among patients with other forms of cancer and non-cancer diseases that may represent a risk factor for development of KS. It was found that the prostate, especially in patients with carcinoma of the prostate and KS could be an important localization of virus and intimate contact with these patients should be limited. For the first time in Russia HIV-negative case of PEL associated with KSHV had been diagnosed and studied in details. It was also demonstrated that isolates of KSHV, circulating in the country, belong to the two major genetic subgroups of the virus (A and C), a widely represented in the European countries and in the United States, which indicates a common origin of the virus in these countries. The current methodologies of KS’ treatment are also presented.
format	article
author	V. E. Gurtsevich L. S. Yakovleva S. A. Galetskiy T. A. Afanasieva N. B. Senjuta V. N. Stepina E. L. Kadyrova D. A. Shirokov M. M. Anokhina T. T Kondratieva N. N. Tupitsin A. Zhessan
author_facet	V. E. Gurtsevich L. S. Yakovleva S. A. Galetskiy T. A. Afanasieva N. B. Senjuta V. N. Stepina E. L. Kadyrova D. A. Shirokov M. M. Anokhina T. T Kondratieva N. N. Tupitsin A. Zhessan
author_sort	V. E. Gurtsevich
title	CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
title_short	CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
title_full	CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
title_fullStr	CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
title_full_unstemmed	CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS
title_sort	clinical and virological characteristics of diseases associated with the kaposi sarcoma virus
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/e1096cd94553435ab54e5ccf59b6ecf3
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CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS

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