Pharmacological inactivation of the prion protein by targeting a folding intermediate

Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizi...

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Autores principales:	Giovanni Spagnolli, Tania Massignan, Andrea Astolfi, Silvia Biggi, Marta Rigoli, Paolo Brunelli, Michela Libergoli, Alan Ianeselli, Simone Orioli, Alberto Boldrini, Luca Terruzzi, Valerio Bonaldo, Giulia Maietta, Nuria L. Lorenzo, Leticia C. Fernandez, Yaiza B. Codeseira, Laura Tosatto, Luise Linsenmeier, Beatrice Vignoli, Gianluca Petris, Dino Gasparotto, Maria Pennuto, Graziano Guella, Marco Canossa, Hermann C. Altmeppen, Graziano Lolli, Stefano Biressi, Manuel M. Pastor, Jesús R. Requena, Ines Mancini, Maria L. Barreca, Pietro Faccioli, Emiliano Biasini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e109df8e1973483785b0d57e6d79e2af
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spelling	oai:doaj.org-article:e109df8e1973483785b0d57e6d79e2af2021-12-02T14:11:54ZPharmacological inactivation of the prion protein by targeting a folding intermediate10.1038/s42003-020-01585-x2399-3642https://doaj.org/article/e109df8e1973483785b0d57e6d79e2af2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01585-xhttps://doaj.org/toc/2399-3642Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.Giovanni SpagnolliTania MassignanAndrea AstolfiSilvia BiggiMarta RigoliPaolo BrunelliMichela LibergoliAlan IaneselliSimone OrioliAlberto BoldriniLuca TerruzziValerio BonaldoGiulia MaiettaNuria L. LorenzoLeticia C. FernandezYaiza B. CodeseiraLaura TosattoLuise LinsenmeierBeatrice VignoliGianluca PetrisDino GasparottoMaria PennutoGraziano GuellaMarco CanossaHermann C. AltmeppenGraziano LolliStefano BiressiManuel M. PastorJesús R. RequenaInes ManciniMaria L. BarrecaPietro FaccioliEmiliano BiasiniNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini Pharmacological inactivation of the prion protein by targeting a folding intermediate
description	Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.
format	article
author	Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini
author_facet	Giovanni Spagnolli Tania Massignan Andrea Astolfi Silvia Biggi Marta Rigoli Paolo Brunelli Michela Libergoli Alan Ianeselli Simone Orioli Alberto Boldrini Luca Terruzzi Valerio Bonaldo Giulia Maietta Nuria L. Lorenzo Leticia C. Fernandez Yaiza B. Codeseira Laura Tosatto Luise Linsenmeier Beatrice Vignoli Gianluca Petris Dino Gasparotto Maria Pennuto Graziano Guella Marco Canossa Hermann C. Altmeppen Graziano Lolli Stefano Biressi Manuel M. Pastor Jesús R. Requena Ines Mancini Maria L. Barreca Pietro Faccioli Emiliano Biasini
author_sort	Giovanni Spagnolli
title	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_short	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_full	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_fullStr	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_full_unstemmed	Pharmacological inactivation of the prion protein by targeting a folding intermediate
title_sort	pharmacological inactivation of the prion protein by targeting a folding intermediate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e109df8e1973483785b0d57e6d79e2af
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Pharmacological inactivation of the prion protein by targeting a folding intermediate

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