Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations

Helicobacter pylori (H. pylori) infection is associated with various gastric and extra-gastric diseases. Importantly, this infection is the strongest known risk factor for gastric cancer (GC). H. pylori eradication can effectively prevent H. pylori infection-associated diseases in H. pylori-positive...

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Autores principales:	Chao Peng, Yi Hu, Zhong-Ming Ge, Quan-Ming Zou, Nong-Hua Lyu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2019
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e10bc3d9caa04849b2eb80dff4e2db94
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spelling	oai:doaj.org-article:e10bc3d9caa04849b2eb80dff4e2db942021-12-02T16:44:33ZDiagnosis and treatment of Helicobacter pylori infections in children and elderly populations2095-882X10.1016/j.cdtm.2019.12.003https://doaj.org/article/e10bc3d9caa04849b2eb80dff4e2db942019-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300891https://doaj.org/toc/2095-882XHelicobacter pylori (H. pylori) infection is associated with various gastric and extra-gastric diseases. Importantly, this infection is the strongest known risk factor for gastric cancer (GC). H. pylori eradication can effectively prevent H. pylori infection-associated diseases in H. pylori-positive patients, including children and elderly subjects. However, a limited selection of antibiotics, a higher reinfection rate, and certain spontaneous clearance rates, to some extent, restrict the choice of H. pylori treatments in pediatrics. In addition, it is imperative to perform an accurate diagnosis of H. pylori infection in children by determining the presence of the H. pylori infection and the underlying cause of symptoms. In elderly patients, poor tolerance to drugs and higher sensitivity to adverse effects are major concerns during H. pylori therapy. Recent studies have demonstrated that H. pylori eradication could significantly lower the GC risk in the elderly population. The benefit and risk of H. pylori eradication in elderly patients should be comprehensively considered and balanced. If available, susceptibility-based tailored therapies may be preferable in eradicating H. pylori. In addition, to increase the eradication rate and reduce adverse effects, new therapeutic strategies (e.g., probiotic supplementation, berberine supplementation, dual therapy) for H. pylori infection are being extensively investigated. The impact of H. pylori eradication with antibiotics on the microbiota in children has been explored, but further high-quality studies are crucial to delineate the extent of H. pylori eradication affecting the microbial community in children. In this review, we summarize the current understanding of H. pylori diagnosis and treatment in children and the elderly population and aim to provide insights into the efficient management and treatment implementation in these populations. Keywords: Children, Elderly, Helicobacter pylori, Diagnosis, TreatmentChao PengYi HuZhong-Ming GeQuan-Ming ZouNong-Hua LyuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 4, Pp 243-251 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chao Peng Yi Hu Zhong-Ming Ge Quan-Ming Zou Nong-Hua Lyu Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
description	Helicobacter pylori (H. pylori) infection is associated with various gastric and extra-gastric diseases. Importantly, this infection is the strongest known risk factor for gastric cancer (GC). H. pylori eradication can effectively prevent H. pylori infection-associated diseases in H. pylori-positive patients, including children and elderly subjects. However, a limited selection of antibiotics, a higher reinfection rate, and certain spontaneous clearance rates, to some extent, restrict the choice of H. pylori treatments in pediatrics. In addition, it is imperative to perform an accurate diagnosis of H. pylori infection in children by determining the presence of the H. pylori infection and the underlying cause of symptoms. In elderly patients, poor tolerance to drugs and higher sensitivity to adverse effects are major concerns during H. pylori therapy. Recent studies have demonstrated that H. pylori eradication could significantly lower the GC risk in the elderly population. The benefit and risk of H. pylori eradication in elderly patients should be comprehensively considered and balanced. If available, susceptibility-based tailored therapies may be preferable in eradicating H. pylori. In addition, to increase the eradication rate and reduce adverse effects, new therapeutic strategies (e.g., probiotic supplementation, berberine supplementation, dual therapy) for H. pylori infection are being extensively investigated. The impact of H. pylori eradication with antibiotics on the microbiota in children has been explored, but further high-quality studies are crucial to delineate the extent of H. pylori eradication affecting the microbial community in children. In this review, we summarize the current understanding of H. pylori diagnosis and treatment in children and the elderly population and aim to provide insights into the efficient management and treatment implementation in these populations. Keywords: Children, Elderly, Helicobacter pylori, Diagnosis, Treatment
format	article
author	Chao Peng Yi Hu Zhong-Ming Ge Quan-Ming Zou Nong-Hua Lyu
author_facet	Chao Peng Yi Hu Zhong-Ming Ge Quan-Ming Zou Nong-Hua Lyu
author_sort	Chao Peng
title	Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
title_short	Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
title_full	Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
title_fullStr	Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
title_full_unstemmed	Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations
title_sort	diagnosis and treatment of helicobacter pylori infections in children and elderly populations
publisher	KeAi Communications Co., Ltd.
publishDate	2019
url	https://doaj.org/article/e10bc3d9caa04849b2eb80dff4e2db94
work_keys_str_mv	AT chaopeng diagnosisandtreatmentofhelicobacterpyloriinfectionsinchildrenandelderlypopulations AT yihu diagnosisandtreatmentofhelicobacterpyloriinfectionsinchildrenandelderlypopulations AT zhongmingge diagnosisandtreatmentofhelicobacterpyloriinfectionsinchildrenandelderlypopulations AT quanmingzou diagnosisandtreatmentofhelicobacterpyloriinfectionsinchildrenandelderlypopulations AT nonghualyu diagnosisandtreatmentofhelicobacterpyloriinfectionsinchildrenandelderlypopulations
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Diagnosis and treatment of Helicobacter pylori infections in children and elderly populations

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