First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia

Devi Oktafiani,1 Ni Luh Ayu Megasari,1,2 Elsa Fitri Ana,1 Nasronudin,1,3 Maria Inge Lusida,2,4 Soetjipto2,3,51Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; 3Universitas Airlangga Hospital, Surabaya, Indone...

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Autores principales:	Oktafiani D, Megasari NLA, Ana EF, Nasronudin, Lusida MI, Soetjipto
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hhv-6 hiv-infected individuals healthy controls surabaya indonesia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e10fab3a84264d29a4f3ea5f3b7722b2
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spelling	oai:doaj.org-article:e10fab3a84264d29a4f3ea5f3b7722b22021-12-02T09:18:00ZFirst Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia1179-1373https://doaj.org/article/e10fab3a84264d29a4f3ea5f3b7722b22020-03-01T00:00:00Zhttps://www.dovepress.com/first-report-on-hhv-6-infection-among-hiv-infected-individuals-residin-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Devi Oktafiani,1 Ni Luh Ayu Megasari,1,2 Elsa Fitri Ana,1 Nasronudin,1,3 Maria Inge Lusida,2,4 Soetjipto2,3,51Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; 3Universitas Airlangga Hospital, Surabaya, Indonesia; 4Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 5Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: SoetjiptoDepartment of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Mayjen Prof. Moestopo Street, No. 47, Surabaya 60131, IndonesiaTel +62 81331340518Email soetjipto1950@gmail.comBackground: Morbidity and mortality from acquired immunodeficiency syndrome (AIDS) are often associated with the reactivation of a herpes virus infection. Human herpesvirus-6 (HHV-6) is usually common in childhood infections that remain latent and can act as opportunists during immunosuppression to reactivate and cause disease. In human immunodeficiency virus (HIV)-infected patients, the impact of HHV-6 infection can be an up-regulator of HIV replication and accelerate progress towards AIDS. However, studies on HHV-6 infection have never been done in Surabaya, Indonesia.Purpose: To determine the presence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia.Patients and Methods: Plasma and peripheral blood mononuclear cells (PBMCs) were collected from 85 HIV-infected individuals in Universitas Airlangga Hospital, Surabaya, as well as 85 healthy controls. DNA extracted from PBMCs was subjected to PCR to determine HHV-6 infection, while plasma of HIV-infected individuals was used for viral RNA quantification using real-time PCR.Results: HHV-6 infection was detected in 17.6% (15/85) of HIV-infected individuals, and in 3.53% (3/85) of healthy controls. Thus, HHV-6 infection was more likely to be found in HIV-infected individuals than in healthy controls (odds ratio 5.85; 95% confidence interval, 1.6– 21). The HHV-6B was the most common subtype identified in both HIV-infected individuals (12/15) and healthy controls (3/3). The HHV-6A and co-infection between HHV-6A and HHV-6B were only found in HIV-infected individuals (2/15 and 1/15, respectively). Viral RNA load of HIV-infected individuals was not correlated to HHV-6 infection.Conclusion: Our results indicate the emergence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia, and the risk of HHV-6 infection was higher in HIV-infected individuals than in healthy controls.Keywords: HHV-6, HIV-infected individuals, healthy controls, Surabaya, IndonesiaOktafiani DMegasari NLAAna EFNasronudinLusida MISoetjiptoDove Medical Pressarticlehhv-6hiv-infected individualshealthy controlssurabayaindonesiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 107-112 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hhv-6 hiv-infected individuals healthy controls surabaya indonesia Immunologic diseases. Allergy RC581-607
spellingShingle	hhv-6 hiv-infected individuals healthy controls surabaya indonesia Immunologic diseases. Allergy RC581-607 Oktafiani D Megasari NLA Ana EF Nasronudin Lusida MI Soetjipto First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
description	Devi Oktafiani,1 Ni Luh Ayu Megasari,1,2 Elsa Fitri Ana,1 Nasronudin,1,3 Maria Inge Lusida,2,4 Soetjipto2,3,51Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; 3Universitas Airlangga Hospital, Surabaya, Indonesia; 4Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 5Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: SoetjiptoDepartment of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Mayjen Prof. Moestopo Street, No. 47, Surabaya 60131, IndonesiaTel +62 81331340518Email soetjipto1950@gmail.comBackground: Morbidity and mortality from acquired immunodeficiency syndrome (AIDS) are often associated with the reactivation of a herpes virus infection. Human herpesvirus-6 (HHV-6) is usually common in childhood infections that remain latent and can act as opportunists during immunosuppression to reactivate and cause disease. In human immunodeficiency virus (HIV)-infected patients, the impact of HHV-6 infection can be an up-regulator of HIV replication and accelerate progress towards AIDS. However, studies on HHV-6 infection have never been done in Surabaya, Indonesia.Purpose: To determine the presence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia.Patients and Methods: Plasma and peripheral blood mononuclear cells (PBMCs) were collected from 85 HIV-infected individuals in Universitas Airlangga Hospital, Surabaya, as well as 85 healthy controls. DNA extracted from PBMCs was subjected to PCR to determine HHV-6 infection, while plasma of HIV-infected individuals was used for viral RNA quantification using real-time PCR.Results: HHV-6 infection was detected in 17.6% (15/85) of HIV-infected individuals, and in 3.53% (3/85) of healthy controls. Thus, HHV-6 infection was more likely to be found in HIV-infected individuals than in healthy controls (odds ratio 5.85; 95% confidence interval, 1.6– 21). The HHV-6B was the most common subtype identified in both HIV-infected individuals (12/15) and healthy controls (3/3). The HHV-6A and co-infection between HHV-6A and HHV-6B were only found in HIV-infected individuals (2/15 and 1/15, respectively). Viral RNA load of HIV-infected individuals was not correlated to HHV-6 infection.Conclusion: Our results indicate the emergence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia, and the risk of HHV-6 infection was higher in HIV-infected individuals than in healthy controls.Keywords: HHV-6, HIV-infected individuals, healthy controls, Surabaya, Indonesia
format	article
author	Oktafiani D Megasari NLA Ana EF Nasronudin Lusida MI Soetjipto
author_facet	Oktafiani D Megasari NLA Ana EF Nasronudin Lusida MI Soetjipto
author_sort	Oktafiani D
title	First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
title_short	First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
title_full	First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
title_fullStr	First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
title_full_unstemmed	First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
title_sort	first report on hhv-6 infection among hiv-infected individuals residing in surabaya, indonesia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e10fab3a84264d29a4f3ea5f3b7722b2
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First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia

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