Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial

M Badrasawi,1,2 Suzana Shahar,1 AM Zahara,1 R Nor Fadilah,3 Devinder Kaur Ajit Singh4 1Dietetic Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Nutrition Program, Faulty of Applied Sciences, Palestine Polytechnic University, Hebron, Palestine; 3Bio...

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Autores principales:	Badrasawi M, Shahar S, Zahara AM, Nor Fadilah R, Singh DKA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Frailty Fried criteria frailty index accumulation of deficit L-carnitine supplementation prefrail elderly physical function frailty biomarkers randomized controlled clinical trial. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e10fe3d4b1134fc98f9e73776fa76b61
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spelling	oai:doaj.org-article:e10fe3d4b1134fc98f9e73776fa76b612021-12-02T00:53:27ZEfficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial1178-1998https://doaj.org/article/e10fe3d4b1134fc98f9e73776fa76b612016-11-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-l-carnitine-supplementation-on-frailty-status-and-its-biom-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998M Badrasawi,1,2 Suzana Shahar,1 AM Zahara,1 R Nor Fadilah,3 Devinder Kaur Ajit Singh4 1Dietetic Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Nutrition Program, Faulty of Applied Sciences, Palestine Polytechnic University, Hebron, Palestine; 3Biomedical Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 4Physiotherapy Programme, School of Rehabilitation Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency, including L-carnitine, has been proposed to be associated with its pathophysiology. Nevertheless, the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus, this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function, cognition, and nutritional status among prefrail older adults in Klang Valley, Malaysia. Methodology: This study is a randomized, double-blind, placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit, selected frailty biomarkers (interleukin-6, tumor necrosis factor-alpha, and insulin-like growth factor-1), physical function, cognitive function, nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P<0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria, four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults. Keywords: frailty, Fried criteria, Frailty Index accumulation of deficit, L-carnitine supplementation, prefrail elderly, physical function, frailty biomarkers, randomized controlled clinical trialBadrasawi MShahar SZahara AMNor Fadilah RSingh DKADove Medical PressarticleFrailtyFried criteriafrailty index accumulation of deficitL-carnitine supplementationprefrail elderlyphysical functionfrailty biomarkersrandomized controlled clinical trial.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1675-1686 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Frailty Fried criteria frailty index accumulation of deficit L-carnitine supplementation prefrail elderly physical function frailty biomarkers randomized controlled clinical trial. Geriatrics RC952-954.6
spellingShingle	Frailty Fried criteria frailty index accumulation of deficit L-carnitine supplementation prefrail elderly physical function frailty biomarkers randomized controlled clinical trial. Geriatrics RC952-954.6 Badrasawi M Shahar S Zahara AM Nor Fadilah R Singh DKA Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
description	M Badrasawi,1,2 Suzana Shahar,1 AM Zahara,1 R Nor Fadilah,3 Devinder Kaur Ajit Singh4 1Dietetic Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Nutrition Program, Faulty of Applied Sciences, Palestine Polytechnic University, Hebron, Palestine; 3Biomedical Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 4Physiotherapy Programme, School of Rehabilitation Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency, including L-carnitine, has been proposed to be associated with its pathophysiology. Nevertheless, the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus, this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function, cognition, and nutritional status among prefrail older adults in Klang Valley, Malaysia. Methodology: This study is a randomized, double-blind, placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit, selected frailty biomarkers (interleukin-6, tumor necrosis factor-alpha, and insulin-like growth factor-1), physical function, cognitive function, nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P<0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria, four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults. Keywords: frailty, Fried criteria, Frailty Index accumulation of deficit, L-carnitine supplementation, prefrail elderly, physical function, frailty biomarkers, randomized controlled clinical trial
format	article
author	Badrasawi M Shahar S Zahara AM Nor Fadilah R Singh DKA
author_facet	Badrasawi M Shahar S Zahara AM Nor Fadilah R Singh DKA
author_sort	Badrasawi M
title	Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
title_short	Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
title_full	Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
title_fullStr	Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
title_full_unstemmed	Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
title_sort	efficacy of l-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/e10fe3d4b1134fc98f9e73776fa76b61
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Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial

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