Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.

Gap junction (GJ) proteins, the primary constituents of GJ channels, are conserved determinants of patterning. Canonically, a GJ channel, made up of two hemi-channels contributed by the neighboring cells, facilitates transport of metabolites/ions. Here we demonstrate the involvement of GJ proteins d...

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Autores principales:	Aresh Sahu, Susnata Karmakar, Sudipta Halder, Gaurab Ghosh, Sayan Acharjee, Purbasa Dasgupta, Ritabrata Ghosh, Girish Deshpande, Mohit Prasad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e1133afd48b8494fa622fc402b8c1541
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spelling	oai:doaj.org-article:e1133afd48b8494fa622fc402b8c15412021-12-02T20:03:24ZGermline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.1553-73901553-740410.1371/journal.pgen.1009685https://doaj.org/article/e1133afd48b8494fa622fc402b8c15412021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009685https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Gap junction (GJ) proteins, the primary constituents of GJ channels, are conserved determinants of patterning. Canonically, a GJ channel, made up of two hemi-channels contributed by the neighboring cells, facilitates transport of metabolites/ions. Here we demonstrate the involvement of GJ proteins during cuboidal to squamous epithelial transition displayed by the anterior follicle cells (AFCs) from Drosophila ovaries. Somatically derived AFCs stretch and flatten when the adjacent germline cells start increasing in size. GJ proteins, Innexin2 (Inx2) and Innexin4 (Inx4), functioning in the AFCs and germline respectively, promote the shape transformation by modulating calcium levels in the AFCs. Our observations suggest that alterations in calcium flux potentiate STAT activity to influence actomyosin-based cytoskeleton, possibly resulting in disassembly of adherens junctions. Our data have uncovered sequential molecular events underlying the cuboidal to squamous shape transition and offer unique insight into how GJ proteins expressed in the neighboring cells contribute to morphogenetic processes.Aresh SahuSusnata KarmakarSudipta HalderGaurab GhoshSayan AcharjeePurbasa DasguptaRitabrata GhoshGirish DeshpandeMohit PrasadPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 8, p e1009685 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Aresh Sahu Susnata Karmakar Sudipta Halder Gaurab Ghosh Sayan Acharjee Purbasa Dasgupta Ritabrata Ghosh Girish Deshpande Mohit Prasad Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
description	Gap junction (GJ) proteins, the primary constituents of GJ channels, are conserved determinants of patterning. Canonically, a GJ channel, made up of two hemi-channels contributed by the neighboring cells, facilitates transport of metabolites/ions. Here we demonstrate the involvement of GJ proteins during cuboidal to squamous epithelial transition displayed by the anterior follicle cells (AFCs) from Drosophila ovaries. Somatically derived AFCs stretch and flatten when the adjacent germline cells start increasing in size. GJ proteins, Innexin2 (Inx2) and Innexin4 (Inx4), functioning in the AFCs and germline respectively, promote the shape transformation by modulating calcium levels in the AFCs. Our observations suggest that alterations in calcium flux potentiate STAT activity to influence actomyosin-based cytoskeleton, possibly resulting in disassembly of adherens junctions. Our data have uncovered sequential molecular events underlying the cuboidal to squamous shape transition and offer unique insight into how GJ proteins expressed in the neighboring cells contribute to morphogenetic processes.
format	article
author	Aresh Sahu Susnata Karmakar Sudipta Halder Gaurab Ghosh Sayan Acharjee Purbasa Dasgupta Ritabrata Ghosh Girish Deshpande Mohit Prasad
author_facet	Aresh Sahu Susnata Karmakar Sudipta Halder Gaurab Ghosh Sayan Acharjee Purbasa Dasgupta Ritabrata Ghosh Girish Deshpande Mohit Prasad
author_sort	Aresh Sahu
title	Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
title_short	Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
title_full	Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
title_fullStr	Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
title_full_unstemmed	Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
title_sort	germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e1133afd48b8494fa622fc402b8c1541
work_keys_str_mv	AT areshsahu germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT susnatakarmakar germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT sudiptahalder germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT gaurabghosh germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT sayanacharjee germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT purbasadasgupta germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT ritabrataghosh germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT girishdeshpande germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis AT mohitprasad germlinesomacommunicationmediatedbygapjunctionproteinsregulatesepithelialmorphogenesis
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Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.

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