Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.

Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-enceph...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chairin Nisa Ma'roef, Rama Dhenni, Dewi Megawati, Araniy Fadhilah, Anton Lucanus, I Made Artika, Sri Masyeni, Asri Lestarini, Kartika Sari, Ketut Suryana, Frilasita A Yudhaputri, Ungke Anton Jaya, R Tedjo Sasmono, Jeremy P Ledermann, Ann M Powers, Khin Saw Aye Myint
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/e1167482141c43b69be46b93663a52e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1167482141c43b69be46b93663a52e9
record_format	dspace
spelling	oai:doaj.org-article:e1167482141c43b69be46b93663a52e92021-12-02T20:23:28ZJapanese encephalitis virus infection in non-encephalitic acute febrile illness patients.1935-27271935-273510.1371/journal.pntd.0008454https://doaj.org/article/e1167482141c43b69be46b93663a52e92020-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0008454https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-encephalitic acute febrile illness patients from Bali, Indonesia. Paired admission (S1) and discharge (S2) serum specimens from 144 acute febrile illness patients (without evidence of acute dengue virus infection) were retrospectively tested for anti-JEV IgM antibody and confirmed by plaque reduction neutralization test (PRNT) for JEV infection. Twenty-six (18.1%) patients were anti-JEV IgM-positive or equivocal in their S2 specimens, of which 5 (3.5%) and 8 (5.6%) patients met the criteria for confirmed and probable JEV infection, respectively, based on PRNT results. Notably, these non-encephalitic JE cases were less likely to have thrombocytopenia, leukopenia, and lower hematocrit compared with confirmed dengue cases of the same cohort. These findings highlight the need to consider JEV in the diagnostic algorithm for acute febrile illnesses in endemic areas and suggest that JEV as a cause of non-encephalitic disease has likely been underestimated in Indonesia.Chairin Nisa Ma'roefRama DhenniDewi MegawatiAraniy FadhilahAnton LucanusI Made ArtikaSri MasyeniAsri LestariniKartika SariKetut SuryanaFrilasita A YudhaputriUngke Anton JayaR Tedjo SasmonoJeremy P LedermannAnn M PowersKhin Saw Aye MyintPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008454 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
description	Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-encephalitic acute febrile illness patients from Bali, Indonesia. Paired admission (S1) and discharge (S2) serum specimens from 144 acute febrile illness patients (without evidence of acute dengue virus infection) were retrospectively tested for anti-JEV IgM antibody and confirmed by plaque reduction neutralization test (PRNT) for JEV infection. Twenty-six (18.1%) patients were anti-JEV IgM-positive or equivocal in their S2 specimens, of which 5 (3.5%) and 8 (5.6%) patients met the criteria for confirmed and probable JEV infection, respectively, based on PRNT results. Notably, these non-encephalitic JE cases were less likely to have thrombocytopenia, leukopenia, and lower hematocrit compared with confirmed dengue cases of the same cohort. These findings highlight the need to consider JEV in the diagnostic algorithm for acute febrile illnesses in endemic areas and suggest that JEV as a cause of non-encephalitic disease has likely been underestimated in Indonesia.
format	article
author	Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint
author_facet	Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint
author_sort	Chairin Nisa Ma'roef
title	Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
title_short	Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
title_full	Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
title_fullStr	Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
title_full_unstemmed	Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
title_sort	japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/e1167482141c43b69be46b93663a52e9
work_keys_str_mv	AT chairinnisamaroef japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT ramadhenni japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT dewimegawati japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT araniyfadhilah japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT antonlucanus japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT imadeartika japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT srimasyeni japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT asrilestarini japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT kartikasari japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT ketutsuryana japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT frilasitaayudhaputri japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT ungkeantonjaya japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT rtedjosasmono japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT jeremypledermann japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT annmpowers japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients AT khinsawayemyint japaneseencephalitisvirusinfectioninnonencephaliticacutefebrileillnesspatients
_version_	1718374138535477248

Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.

Ejemplares similares