MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.

Milk is the primary source of nutrition for young mammals including humans. The nutritional value of milk is mainly attributable to fats and proteins fractions. In comparison to cow milk, goat milk contains greater amounts of total fat, including much higher levels of the beneficial unsaturated fatt...

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Autores principales:	Xianzi Lin, Jun Luo, Liping Zhang, Wei Wang, Deming Gou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e118d783705a4cd1ab4bd3a8a39641a7
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spelling	oai:doaj.org-article:e118d783705a4cd1ab4bd3a8a39641a72021-11-18T08:47:26ZMiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.1932-620310.1371/journal.pone.0079258https://doaj.org/article/e118d783705a4cd1ab4bd3a8a39641a72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244462/?tool=EBIhttps://doaj.org/toc/1932-6203Milk is the primary source of nutrition for young mammals including humans. The nutritional value of milk is mainly attributable to fats and proteins fractions. In comparison to cow milk, goat milk contains greater amounts of total fat, including much higher levels of the beneficial unsaturated fatty acids. MicroRNAs (miRNAs), a well-defined group of small RNAs containing about 22 nucleotides (nt), participate in various metabolic processes across species. However, little is known regarding the role of miRNAs in regulating goat milk composition. In the present study, we performed high-throughput sequencing to identify mammary gland-enriched miRNAs in lactating goats. We identified 30 highly expressed miRNAs in the mammary gland, including miR-103. Further studies revealed that miR-103 expression correlates with the lactation. Further functional analysis showed that over-expression of miR-103 in mammary gland epithelial cells increases transcription of genes associated with milk fat synthesis, resulting in an up-regulation of fat droplet formation, triglyceride accumulation, and the proportion of unsaturated fatty acids. This study provides new insight into the functions of miR-103, as well as the molecular mechanisms that regulate milk fat synthesis.Xianzi LinJun LuoLiping ZhangWei WangDeming GouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79258 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xianzi Lin Jun Luo Liping Zhang Wei Wang Deming Gou MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
description	Milk is the primary source of nutrition for young mammals including humans. The nutritional value of milk is mainly attributable to fats and proteins fractions. In comparison to cow milk, goat milk contains greater amounts of total fat, including much higher levels of the beneficial unsaturated fatty acids. MicroRNAs (miRNAs), a well-defined group of small RNAs containing about 22 nucleotides (nt), participate in various metabolic processes across species. However, little is known regarding the role of miRNAs in regulating goat milk composition. In the present study, we performed high-throughput sequencing to identify mammary gland-enriched miRNAs in lactating goats. We identified 30 highly expressed miRNAs in the mammary gland, including miR-103. Further studies revealed that miR-103 expression correlates with the lactation. Further functional analysis showed that over-expression of miR-103 in mammary gland epithelial cells increases transcription of genes associated with milk fat synthesis, resulting in an up-regulation of fat droplet formation, triglyceride accumulation, and the proportion of unsaturated fatty acids. This study provides new insight into the functions of miR-103, as well as the molecular mechanisms that regulate milk fat synthesis.
format	article
author	Xianzi Lin Jun Luo Liping Zhang Wei Wang Deming Gou
author_facet	Xianzi Lin Jun Luo Liping Zhang Wei Wang Deming Gou
author_sort	Xianzi Lin
title	MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
title_short	MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
title_full	MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
title_fullStr	MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
title_full_unstemmed	MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.
title_sort	mir-103 controls milk fat accumulation in goat (capra hircus) mammary gland during lactation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e118d783705a4cd1ab4bd3a8a39641a7
work_keys_str_mv	AT xianzilin mir103controlsmilkfataccumulationingoatcaprahircusmammaryglandduringlactation AT junluo mir103controlsmilkfataccumulationingoatcaprahircusmammaryglandduringlactation AT lipingzhang mir103controlsmilkfataccumulationingoatcaprahircusmammaryglandduringlactation AT weiwang mir103controlsmilkfataccumulationingoatcaprahircusmammaryglandduringlactation AT deminggou mir103controlsmilkfataccumulationingoatcaprahircusmammaryglandduringlactation
_version_	1718421354876764160

MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.

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