Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy

Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a p...

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Autores principales:	Yui Yamashita, Yuki Hashimoto, Kenichi Namba, Kazuomi Mizuuchi, Susumu Ishida
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	anterior ischemic optic neuropathy laser speckle flowgraphy optical coherence tomography optic nerve head microcirculation vogt-koyanagi-harada disease Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e122ca0e8d4b4798885f379c1ba4f9da
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spelling	oai:doaj.org-article:e122ca0e8d4b4798885f379c1ba4f9da2021-12-02T12:40:23ZOptic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy1663-269910.1159/000520036https://doaj.org/article/e122ca0e8d4b4798885f379c1ba4f9da2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520036https://doaj.org/toc/1663-2699Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a patient with VKH disease accompanied by AION. A 65-year-old female complained of blurred vision in both of her eyes. The patient presented with optic disc swelling and remarkable choroidal thickening detected by OCT bilaterally. The diagnosis of VKH disease was established based on the presence of pleocytosis detected in the cerebrospinal fluid and hypofluorescent dark dots scattered all around the fundus, detected by indocyanine green angiography. Goldmann perimetry detected visual field defects, similar to superior altitudinal hemianopsia in the right eye and similar to inferior altitudinal hemianopsia in the left eye. The patient was suspected to have developed AION in both eyes. The patient received methylprednisolone pulse therapy, followed by oral prednisolone. With these treatments, the optic disc swelling disappeared. However, optic disc atrophy with visual field defects remained in both eyes. An OCT C-scan showed the ganglion cell complex (GCC) and circumpapillary retinal nerve fiber layer (cpRNFL) thickness getting thinner below the normal range, and LSFG showed the decrease in optic nerve head (ONH) tissue microcirculation. These results supported the occurrence of AION in this patient with VKH disease. The analysis of GCC and cpRNFL thickness and ONH microcirculation would be useful for supporting the occurrence of AION in a case of VKH disease.Yui YamashitaYuki HashimotoKenichi NambaKazuomi MizuuchiSusumu IshidaKarger Publishersarticleanterior ischemic optic neuropathylaser speckle flowgraphyoptical coherence tomographyoptic nerve head microcirculationvogt-koyanagi-harada diseaseOphthalmologyRE1-994ENCase Reports in Ophthalmology, Vol 12, Iss 3, Pp 899-908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anterior ischemic optic neuropathy laser speckle flowgraphy optical coherence tomography optic nerve head microcirculation vogt-koyanagi-harada disease Ophthalmology RE1-994
spellingShingle	anterior ischemic optic neuropathy laser speckle flowgraphy optical coherence tomography optic nerve head microcirculation vogt-koyanagi-harada disease Ophthalmology RE1-994 Yui Yamashita Yuki Hashimoto Kenichi Namba Kazuomi Mizuuchi Susumu Ishida Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
description	Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a patient with VKH disease accompanied by AION. A 65-year-old female complained of blurred vision in both of her eyes. The patient presented with optic disc swelling and remarkable choroidal thickening detected by OCT bilaterally. The diagnosis of VKH disease was established based on the presence of pleocytosis detected in the cerebrospinal fluid and hypofluorescent dark dots scattered all around the fundus, detected by indocyanine green angiography. Goldmann perimetry detected visual field defects, similar to superior altitudinal hemianopsia in the right eye and similar to inferior altitudinal hemianopsia in the left eye. The patient was suspected to have developed AION in both eyes. The patient received methylprednisolone pulse therapy, followed by oral prednisolone. With these treatments, the optic disc swelling disappeared. However, optic disc atrophy with visual field defects remained in both eyes. An OCT C-scan showed the ganglion cell complex (GCC) and circumpapillary retinal nerve fiber layer (cpRNFL) thickness getting thinner below the normal range, and LSFG showed the decrease in optic nerve head (ONH) tissue microcirculation. These results supported the occurrence of AION in this patient with VKH disease. The analysis of GCC and cpRNFL thickness and ONH microcirculation would be useful for supporting the occurrence of AION in a case of VKH disease.
format	article
author	Yui Yamashita Yuki Hashimoto Kenichi Namba Kazuomi Mizuuchi Susumu Ishida
author_facet	Yui Yamashita Yuki Hashimoto Kenichi Namba Kazuomi Mizuuchi Susumu Ishida
author_sort	Yui Yamashita
title	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
title_short	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
title_full	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
title_fullStr	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
title_full_unstemmed	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
title_sort	optic nerve head microcirculation in eyes with vogt-koyanagi-harada disease accompanied by anterior ischemic optic neuropathy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/e122ca0e8d4b4798885f379c1ba4f9da
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Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy

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