Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.

A recent study revealed that Slitrk6, a transmembrane protein containing a leucine-rich repeat domain, has a critical role in the development of the inner ear neural circuit. However, it is still unknown how the absence of Slitrk6 affects auditory and vestibular functions. In addition, the role of S...

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Autores principales:	Yoshifumi Matsumoto, Kei-ichi Katayama, Takehito Okamoto, Kazuyuki Yamada, Noriko Takashima, Soichi Nagao, Jun Aruga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e128d9fecd934c4f843fabbc2cb03f2d
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spelling	oai:doaj.org-article:e128d9fecd934c4f843fabbc2cb03f2d2021-11-18T06:59:51ZImpaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.1932-620310.1371/journal.pone.0016497https://doaj.org/article/e128d9fecd934c4f843fabbc2cb03f2d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21298075/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A recent study revealed that Slitrk6, a transmembrane protein containing a leucine-rich repeat domain, has a critical role in the development of the inner ear neural circuit. However, it is still unknown how the absence of Slitrk6 affects auditory and vestibular functions. In addition, the role of Slitrk6 in regions of the central nervous system, including the dorsal thalamus, has not been addressed. To understand the physiological role of Slitrk6, Slitrk6-knockout (KO) mice were subjected to systematic behavioral analyses including auditory and vestibular function tests. Compared to wild-type mice, the auditory brainstem response (ABR) of Slitrk6-KO mice indicated a mid-frequency range (8-16 kHz) hearing loss and reduction of the first ABR wave. The auditory startle response was also reduced. A vestibulo-ocular reflex (VOR) test showed decreased vertical (head movement-induced) VOR gains and normal horizontal VOR. In an open field test, locomotor activity was reduced; the tendency to be in the center region was increased, but only in the first 5 min of the test, indicating altered adaptive responses to a novel environment. Altered adaptive responses were also found in a hole-board test in which head-dip behavior was increased and advanced. Aside from these abnormalities, no clear abnormalities were noted in the mood, anxiety, learning, spatial memory, or fear memory-related behavioral tests. These results indicate that the Slitrk6-KO mouse can serve as a model of hereditary sensorineural deafness. Furthermore, the altered responses of Slitrk6-KO mice to the novel environment suggest a role of Slitrk6 in some cognitive functions.Yoshifumi MatsumotoKei-ichi KatayamaTakehito OkamotoKazuyuki YamadaNoriko TakashimaSoichi NagaoJun ArugaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16497 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshifumi Matsumoto Kei-ichi Katayama Takehito Okamoto Kazuyuki Yamada Noriko Takashima Soichi Nagao Jun Aruga Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
description	A recent study revealed that Slitrk6, a transmembrane protein containing a leucine-rich repeat domain, has a critical role in the development of the inner ear neural circuit. However, it is still unknown how the absence of Slitrk6 affects auditory and vestibular functions. In addition, the role of Slitrk6 in regions of the central nervous system, including the dorsal thalamus, has not been addressed. To understand the physiological role of Slitrk6, Slitrk6-knockout (KO) mice were subjected to systematic behavioral analyses including auditory and vestibular function tests. Compared to wild-type mice, the auditory brainstem response (ABR) of Slitrk6-KO mice indicated a mid-frequency range (8-16 kHz) hearing loss and reduction of the first ABR wave. The auditory startle response was also reduced. A vestibulo-ocular reflex (VOR) test showed decreased vertical (head movement-induced) VOR gains and normal horizontal VOR. In an open field test, locomotor activity was reduced; the tendency to be in the center region was increased, but only in the first 5 min of the test, indicating altered adaptive responses to a novel environment. Altered adaptive responses were also found in a hole-board test in which head-dip behavior was increased and advanced. Aside from these abnormalities, no clear abnormalities were noted in the mood, anxiety, learning, spatial memory, or fear memory-related behavioral tests. These results indicate that the Slitrk6-KO mouse can serve as a model of hereditary sensorineural deafness. Furthermore, the altered responses of Slitrk6-KO mice to the novel environment suggest a role of Slitrk6 in some cognitive functions.
format	article
author	Yoshifumi Matsumoto Kei-ichi Katayama Takehito Okamoto Kazuyuki Yamada Noriko Takashima Soichi Nagao Jun Aruga
author_facet	Yoshifumi Matsumoto Kei-ichi Katayama Takehito Okamoto Kazuyuki Yamada Noriko Takashima Soichi Nagao Jun Aruga
author_sort	Yoshifumi Matsumoto
title	Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
title_short	Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
title_full	Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
title_fullStr	Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
title_full_unstemmed	Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
title_sort	impaired auditory-vestibular functions and behavioral abnormalities of slitrk6-deficient mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e128d9fecd934c4f843fabbc2cb03f2d
work_keys_str_mv	AT yoshifumimatsumoto impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT keiichikatayama impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT takehitookamoto impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT kazuyukiyamada impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT norikotakashima impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT soichinagao impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice AT junaruga impairedauditoryvestibularfunctionsandbehavioralabnormalitiesofslitrk6deficientmice
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Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.

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