EGR-2 is not required for in vivo CD4 T cell mediated immune responses.

<h4>Background</h4>The zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell tolerance. In vitro, a prior study has show that T cells deficient in EGR-2 are hyperproliferative to IL-2 and...

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Autores principales:	Hilda E Ramón, Pedro J Cejas, David LaRosa, Adeeb Rahman, John E Harris, Jidong Zhang, Christopher Hunter, Yongwon Choi, Laurence A Turka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e12be66e2b8442d0b9e35c38c7646539
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spelling	oai:doaj.org-article:e12be66e2b8442d0b9e35c38c76465392021-11-18T06:34:48ZEGR-2 is not required for in vivo CD4 T cell mediated immune responses.1932-620310.1371/journal.pone.0012904https://doaj.org/article/e12be66e2b8442d0b9e35c38c76465392010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886122/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell tolerance. In vitro, a prior study has show that T cells deficient in EGR-2 are hyperproliferative to IL-2 and produce elevated levels of the effector cytokine IFN-γ. EGR-2 deficient mice have increased levels of CD44(high) T cells in peripheral lymphoid organs, and with age, develop autoimmune-like features.<h4>Principal findings</h4>Here we show that despite increased numbers of cells bearing an activated CD44(high)CD62L(low) phenotype, T cells from young healthy EGR-2 deficient mice have normal proliferative and cytokine responses, and the mice themselves mount normal immune responses against minor histocompatibility antigens, and the pathogens Toxoplasma gondii and lymphocytic choriomeningitis virus.<h4>Conclusions</h4>Our results indicate that EGR-2 is not required to mount normal acute in vivo immune responses against foreign antigens, and suggest instead that it may serve to regulate the response to chronic antigenic exposure, such as that which occurs to autoantigens.Hilda E RamónPedro J CejasDavid LaRosaAdeeb RahmanJohn E HarrisJidong ZhangChristopher HunterYongwon ChoiLaurence A TurkaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 9, p e12904 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hilda E Ramón Pedro J Cejas David LaRosa Adeeb Rahman John E Harris Jidong Zhang Christopher Hunter Yongwon Choi Laurence A Turka EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
description	<h4>Background</h4>The zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell tolerance. In vitro, a prior study has show that T cells deficient in EGR-2 are hyperproliferative to IL-2 and produce elevated levels of the effector cytokine IFN-γ. EGR-2 deficient mice have increased levels of CD44(high) T cells in peripheral lymphoid organs, and with age, develop autoimmune-like features.<h4>Principal findings</h4>Here we show that despite increased numbers of cells bearing an activated CD44(high)CD62L(low) phenotype, T cells from young healthy EGR-2 deficient mice have normal proliferative and cytokine responses, and the mice themselves mount normal immune responses against minor histocompatibility antigens, and the pathogens Toxoplasma gondii and lymphocytic choriomeningitis virus.<h4>Conclusions</h4>Our results indicate that EGR-2 is not required to mount normal acute in vivo immune responses against foreign antigens, and suggest instead that it may serve to regulate the response to chronic antigenic exposure, such as that which occurs to autoantigens.
format	article
author	Hilda E Ramón Pedro J Cejas David LaRosa Adeeb Rahman John E Harris Jidong Zhang Christopher Hunter Yongwon Choi Laurence A Turka
author_facet	Hilda E Ramón Pedro J Cejas David LaRosa Adeeb Rahman John E Harris Jidong Zhang Christopher Hunter Yongwon Choi Laurence A Turka
author_sort	Hilda E Ramón
title	EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
title_short	EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
title_full	EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
title_fullStr	EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
title_full_unstemmed	EGR-2 is not required for in vivo CD4 T cell mediated immune responses.
title_sort	egr-2 is not required for in vivo cd4 t cell mediated immune responses.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e12be66e2b8442d0b9e35c38c7646539
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EGR-2 is not required for in vivo CD4 T cell mediated immune responses.

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