GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

The sweetener D-allulose has beneficial metabolic effects in animal models, but its mechanism of action was unclear. Here the authors report that D-allulose triggers GLP-1 release in the gut and GLP-1R signaling on vagal afferents, counteracting arrhythmic overeating, obesity and diabetes.

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Autores principales:	Yusaku Iwasaki, Mio Sendo, Katsuya Dezaki, Tohru Hira, Takehiro Sato, Masanori Nakata, Chayon Goswami, Ryohei Aoki, Takeshi Arai, Parmila Kumari, Masaki Hayakawa, Chiaki Masuda, Takashi Okada, Hiroshi Hara, Daniel J. Drucker, Yuichiro Yamada, Masaaki Tokuda, Toshihiko Yada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e12ee17a7b5b43b1bfe21f19dd080e2a
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spelling	oai:doaj.org-article:e12ee17a7b5b43b1bfe21f19dd080e2a2021-12-02T14:41:05ZGLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose10.1038/s41467-017-02488-y2041-1723https://doaj.org/article/e12ee17a7b5b43b1bfe21f19dd080e2a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02488-yhttps://doaj.org/toc/2041-1723The sweetener D-allulose has beneficial metabolic effects in animal models, but its mechanism of action was unclear. Here the authors report that D-allulose triggers GLP-1 release in the gut and GLP-1R signaling on vagal afferents, counteracting arrhythmic overeating, obesity and diabetes.Yusaku IwasakiMio SendoKatsuya DezakiTohru HiraTakehiro SatoMasanori NakataChayon GoswamiRyohei AokiTakeshi AraiParmila KumariMasaki HayakawaChiaki MasudaTakashi OkadaHiroshi HaraDaniel J. DruckerYuichiro YamadaMasaaki TokudaToshihiko YadaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusaku Iwasaki Mio Sendo Katsuya Dezaki Tohru Hira Takehiro Sato Masanori Nakata Chayon Goswami Ryohei Aoki Takeshi Arai Parmila Kumari Masaki Hayakawa Chiaki Masuda Takashi Okada Hiroshi Hara Daniel J. Drucker Yuichiro Yamada Masaaki Tokuda Toshihiko Yada GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
description	The sweetener D-allulose has beneficial metabolic effects in animal models, but its mechanism of action was unclear. Here the authors report that D-allulose triggers GLP-1 release in the gut and GLP-1R signaling on vagal afferents, counteracting arrhythmic overeating, obesity and diabetes.
format	article
author	Yusaku Iwasaki Mio Sendo Katsuya Dezaki Tohru Hira Takehiro Sato Masanori Nakata Chayon Goswami Ryohei Aoki Takeshi Arai Parmila Kumari Masaki Hayakawa Chiaki Masuda Takashi Okada Hiroshi Hara Daniel J. Drucker Yuichiro Yamada Masaaki Tokuda Toshihiko Yada
author_facet	Yusaku Iwasaki Mio Sendo Katsuya Dezaki Tohru Hira Takehiro Sato Masanori Nakata Chayon Goswami Ryohei Aoki Takeshi Arai Parmila Kumari Masaki Hayakawa Chiaki Masuda Takashi Okada Hiroshi Hara Daniel J. Drucker Yuichiro Yamada Masaaki Tokuda Toshihiko Yada
author_sort	Yusaku Iwasaki
title	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
title_short	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
title_full	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
title_fullStr	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
title_full_unstemmed	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
title_sort	glp-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of d-allulose
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e12ee17a7b5b43b1bfe21f19dd080e2a
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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

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