Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study

Yifeng Qian,1– 3,* Huiting Yu,4,* Weijun Yuan,1– 3,* Jiaqing Wu,5 Qingyu Xu,5 Nianrou Mei,5 Xudong Wang,1– 3 Chunfang Wang4 1Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong Univers...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Y, Yu H, Yuan W, Wu J, Xu Q, Mei N, Wang X, Wang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	periodontitis alveolar bone loss tooth loss oral cancer prevention Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e12f3123c4e1453f896de97543c7d712
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e12f3123c4e1453f896de97543c7d712
record_format	dspace
spelling	oai:doaj.org-article:e12f3123c4e1453f896de97543c7d7122021-12-02T12:57:14ZAlveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study1178-1998https://doaj.org/article/e12f3123c4e1453f896de97543c7d7122020-08-01T00:00:00Zhttps://www.dovepress.com/alveolar-bone-loss-tooth-loss-and-oral-cancer-mortality-in-older-patie-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yifeng Qian,1– 3,* Huiting Yu,4,* Weijun Yuan,1– 3,* Jiaqing Wu,5 Qingyu Xu,5 Nianrou Mei,5 Xudong Wang,1– 3 Chunfang Wang4 1Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2National Clinical Research Center for Oral Diseases, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People’s Republic of China; 4Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of China; 5College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Wang; Chunfang Wang Email xudongwang70@hotmail.com; qyf208@163.comPurpose: There has been growing interest in the association between periodontitis and systemic disease. In recent years, however, inconsistent results have also been found by case–control studies for the role of periodontitis in the development of oral cancer. This study aimed to examine whether periodontitis was an independent risk factor for oral cancer with a ≥ 75-year age group cohort.Materials and Methods: Between January 2010 and December 2014, 1385 patients aged ≥ 75 years who underwent radiographic examination were included in this retrospective cohort study. We collected demographic information and comorbid health conditions from local health authorities. Participants were followed up until either the occurrence of mortality, or the end of the study on December 31, 2018. Cox proportional hazards regression and competing risk hazard models were used to examine the association between periodontitis and oral cancer mortality.Results: Periodontitis and loss of teeth were significantly associated with oral cancer mortality. Compared to oral cancer mortality in healthy subjects, the HR and 95% CI in patients with mild, moderate, and severe periodontitis were 4.46 (0.94– 21.06), 5.16 (1.14– 23.39), and 6.65 (1.51– 29.36), respectively. The HR (95% CI) was 1.05 (1.01– 1.09) for tooth loss after controlling for potential confounding factors. All the increases in risk persisted in patients aged ≥ 80 years.Conclusion: The present study provides substantial evidence that poor periodontal health is associated with oral cancer mortality. It is necessary to underline the importance of considering periodontitis in the prevention of oral cancer, particularly in the older patients.Keywords: periodontitis, alveolar bone loss, tooth loss, oral cancer, preventionQian YYu HYuan WWu JXu QMei NWang XWang CDove Medical Pressarticleperiodontitisalveolar bone losstooth lossoral cancerpreventionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1419-1425 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	periodontitis alveolar bone loss tooth loss oral cancer prevention Geriatrics RC952-954.6
spellingShingle	periodontitis alveolar bone loss tooth loss oral cancer prevention Geriatrics RC952-954.6 Qian Y Yu H Yuan W Wu J Xu Q Mei N Wang X Wang C Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
description	Yifeng Qian,1– 3,* Huiting Yu,4,* Weijun Yuan,1– 3,* Jiaqing Wu,5 Qingyu Xu,5 Nianrou Mei,5 Xudong Wang,1– 3 Chunfang Wang4 1Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2National Clinical Research Center for Oral Diseases, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People’s Republic of China; 4Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of China; 5College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Wang; Chunfang Wang Email xudongwang70@hotmail.com; qyf208@163.comPurpose: There has been growing interest in the association between periodontitis and systemic disease. In recent years, however, inconsistent results have also been found by case–control studies for the role of periodontitis in the development of oral cancer. This study aimed to examine whether periodontitis was an independent risk factor for oral cancer with a ≥ 75-year age group cohort.Materials and Methods: Between January 2010 and December 2014, 1385 patients aged ≥ 75 years who underwent radiographic examination were included in this retrospective cohort study. We collected demographic information and comorbid health conditions from local health authorities. Participants were followed up until either the occurrence of mortality, or the end of the study on December 31, 2018. Cox proportional hazards regression and competing risk hazard models were used to examine the association between periodontitis and oral cancer mortality.Results: Periodontitis and loss of teeth were significantly associated with oral cancer mortality. Compared to oral cancer mortality in healthy subjects, the HR and 95% CI in patients with mild, moderate, and severe periodontitis were 4.46 (0.94– 21.06), 5.16 (1.14– 23.39), and 6.65 (1.51– 29.36), respectively. The HR (95% CI) was 1.05 (1.01– 1.09) for tooth loss after controlling for potential confounding factors. All the increases in risk persisted in patients aged ≥ 80 years.Conclusion: The present study provides substantial evidence that poor periodontal health is associated with oral cancer mortality. It is necessary to underline the importance of considering periodontitis in the prevention of oral cancer, particularly in the older patients.Keywords: periodontitis, alveolar bone loss, tooth loss, oral cancer, prevention
format	article
author	Qian Y Yu H Yuan W Wu J Xu Q Mei N Wang X Wang C
author_facet	Qian Y Yu H Yuan W Wu J Xu Q Mei N Wang X Wang C
author_sort	Qian Y
title	Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
title_short	Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
title_full	Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
title_fullStr	Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
title_full_unstemmed	Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study
title_sort	alveolar bone loss, tooth loss and oral cancer mortality in older patients: a retrospective cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e12f3123c4e1453f896de97543c7d712
work_keys_str_mv	AT qiany alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT yuh alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT yuanw alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT wuj alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT xuq alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT mein alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT wangx alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy AT wangc alveolarbonelosstoothlossandoralcancermortalityinolderpatientsaretrospectivecohortstudy
_version_	1718393596902637568

Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study

Ejemplares similares