Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico

Abstract Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatmen...

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Autores principales:	Karla Saavedra-Rodriguez, Farah Vera Maloof, Corey L. Campbell, Julian Garcia-Rejon, Audrey Lenhart, Patricia Penilla, Americo Rodriguez, Arturo Acero Sandoval, Adriana E. Flores, Gustavo Ponce, Saul Lozano, William C. Black
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e131e36160414ebbabe74510825276d0
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spelling	oai:doaj.org-article:e131e36160414ebbabe74510825276d02021-12-02T16:08:26ZParallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico10.1038/s41598-018-25222-02045-2322https://doaj.org/article/e131e36160414ebbabe74510825276d02018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25222-0https://doaj.org/toc/2045-2322Abstract Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identified in Brazil and its effect on vgsc was confirmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the first heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specific vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.Karla Saavedra-RodriguezFarah Vera MaloofCorey L. CampbellJulian Garcia-RejonAudrey LenhartPatricia PenillaAmerico RodriguezArturo Acero SandovalAdriana E. FloresGustavo PonceSaul LozanoWilliam C. BlackNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karla Saavedra-Rodriguez Farah Vera Maloof Corey L. Campbell Julian Garcia-Rejon Audrey Lenhart Patricia Penilla Americo Rodriguez Arturo Acero Sandoval Adriana E. Flores Gustavo Ponce Saul Lozano William C. Black Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
description	Abstract Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identified in Brazil and its effect on vgsc was confirmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the first heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specific vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.
format	article
author	Karla Saavedra-Rodriguez Farah Vera Maloof Corey L. Campbell Julian Garcia-Rejon Audrey Lenhart Patricia Penilla Americo Rodriguez Arturo Acero Sandoval Adriana E. Flores Gustavo Ponce Saul Lozano William C. Black
author_facet	Karla Saavedra-Rodriguez Farah Vera Maloof Corey L. Campbell Julian Garcia-Rejon Audrey Lenhart Patricia Penilla Americo Rodriguez Arturo Acero Sandoval Adriana E. Flores Gustavo Ponce Saul Lozano William C. Black
author_sort	Karla Saavedra-Rodriguez
title	Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
title_short	Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
title_full	Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
title_fullStr	Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
title_full_unstemmed	Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
title_sort	parallel evolution of vgsc mutations at domains is6, iis6 and iiis6 in pyrethroid resistant aedes aegypti from mexico
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e131e36160414ebbabe74510825276d0
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Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico

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