A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats

Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China and other Eastern Asian countries. Only few research has been done on toxicological profiling of mulberry extract for its safety evaluation; however, the data is inconclusive. In t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Min Hong MD, PhD, Min Lu MS, Yimin Qian MS, Liping Wei MS, Yaqun Zhang MS, Xueying Pan PhD, Hua Li PhD, Huaying Chen PhD, Naping Tang PhD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/e1334f4252d54ba6a587c06b55bca5a6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1334f4252d54ba6a587c06b55bca5a6
record_format	dspace
spelling	oai:doaj.org-article:e1334f4252d54ba6a587c06b55bca5a62021-11-23T23:04:19ZA 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats0046-95801945-724310.1177/00469580211056044https://doaj.org/article/e1334f4252d54ba6a587c06b55bca5a62021-11-01T00:00:00Zhttps://doi.org/10.1177/00469580211056044https://doaj.org/toc/0046-9580https://doaj.org/toc/1945-7243Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China and other Eastern Asian countries. Only few research has been done on toxicological profiling of mulberry extract for its safety evaluation; however, the data is inconclusive. In the current study, mulberry extract of 4200, 1400, or 466 mg/kg were orally administrated to Sprague Dawley rats for 90 consecutive days followed by a recovery period of 28 days. No abnormalities were detected in body weights, food intake, ophthalmological, hematological, coagulation, clinical chemistry, and organ weights parameters. Discoloration of urine (red, purple, and brown) and feces (black), along with bedding material (purple) were observed in the 4200 mg/kg group. Further, microscopic examination revealed brown granules in the renal tubular cells for rats in 4200 and 1400 mg/kg groups. Since these changes were associated with excretory effect of the extract, the No Observed Adverse Effect Level was determined to be 4200 mg/kg, which was equivalent to the 1058.5 mg/kg of anthocyanin.Min Hong MD, PhDMin Lu MSYimin Qian MSLiping Wei MSYaqun Zhang MSXueying Pan PhDHua Li PhDHuaying Chen PhDNaping Tang PhDSAGE PublishingarticlePublic aspects of medicineRA1-1270ENInquiry: The Journal of Health Care Organization, Provision, and Financing, Vol 58 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Min Hong MD, PhD Min Lu MS Yimin Qian MS Liping Wei MS Yaqun Zhang MS Xueying Pan PhD Hua Li PhD Huaying Chen PhD Naping Tang PhD A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
description	Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China and other Eastern Asian countries. Only few research has been done on toxicological profiling of mulberry extract for its safety evaluation; however, the data is inconclusive. In the current study, mulberry extract of 4200, 1400, or 466 mg/kg were orally administrated to Sprague Dawley rats for 90 consecutive days followed by a recovery period of 28 days. No abnormalities were detected in body weights, food intake, ophthalmological, hematological, coagulation, clinical chemistry, and organ weights parameters. Discoloration of urine (red, purple, and brown) and feces (black), along with bedding material (purple) were observed in the 4200 mg/kg group. Further, microscopic examination revealed brown granules in the renal tubular cells for rats in 4200 and 1400 mg/kg groups. Since these changes were associated with excretory effect of the extract, the No Observed Adverse Effect Level was determined to be 4200 mg/kg, which was equivalent to the 1058.5 mg/kg of anthocyanin.
format	article
author	Min Hong MD, PhD Min Lu MS Yimin Qian MS Liping Wei MS Yaqun Zhang MS Xueying Pan PhD Hua Li PhD Huaying Chen PhD Naping Tang PhD
author_facet	Min Hong MD, PhD Min Lu MS Yimin Qian MS Liping Wei MS Yaqun Zhang MS Xueying Pan PhD Hua Li PhD Huaying Chen PhD Naping Tang PhD
author_sort	Min Hong MD, PhD
title	A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
title_short	A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
title_full	A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
title_fullStr	A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
title_full_unstemmed	A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
title_sort	90-day sub-chronic oral toxicity assessment of mulberry extract in sprague dawley rats
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/e1334f4252d54ba6a587c06b55bca5a6
work_keys_str_mv	AT minhongmdphd a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT minlums a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT yiminqianms a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT lipingweims a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT yaqunzhangms a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT xueyingpanphd a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT hualiphd a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT huayingchenphd a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT napingtangphd a90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT minhongmdphd 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT minlums 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT yiminqianms 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT lipingweims 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT yaqunzhangms 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT xueyingpanphd 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT hualiphd 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT huayingchenphd 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats AT napingtangphd 90daysubchronicoraltoxicityassessmentofmulberryextractinspraguedawleyrats
_version_	1718416125919756288

A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats

Ejemplares similares