Thrombopoiesis is spatially regulated by the bone marrow vasculature
Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.
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Nature Portfolio
2017
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oai:doaj.org-article:e135bb3de3894d00826f43b38e69be3f2021-12-02T13:24:14ZThrombopoiesis is spatially regulated by the bone marrow vasculature10.1038/s41467-017-00201-72041-1723https://doaj.org/article/e135bb3de3894d00826f43b38e69be3f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00201-7https://doaj.org/toc/2041-1723Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.David StegnerJudith M. M. vanEeuwijkOğuzhan AngayMaximilian G. GorelashviliDaniela SemeniakJürgen PinneckerPatrick SchmithausenImke MeyerMike FriedrichSebastian DüttingChristian BredeAndreas BeilhackHarald SchulzeBernhard NieswandtKatrin G. HeinzeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| description |
Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow. |
| format |
article |
| author |
David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze |
| author_facet |
David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze |
| author_sort |
David Stegner |
| title |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_short |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_full |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_fullStr |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_full_unstemmed |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_sort |
thrombopoiesis is spatially regulated by the bone marrow vasculature |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e135bb3de3894d00826f43b38e69be3f |
| work_keys_str_mv |
AT davidstegner thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT judithmmvaneeuwijk thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT oguzhanangay thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT maximilianggorelashvili thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT danielasemeniak thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT jurgenpinnecker thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT patrickschmithausen thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT imkemeyer thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT mikefriedrich thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT sebastiandutting thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT christianbrede thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT andreasbeilhack thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT haraldschulze thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT bernhardnieswandt thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature AT katringheinze thrombopoiesisisspatiallyregulatedbythebonemarrowvasculature |
| _version_ |
1718393124954308608 |