Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical distinct diosgenin-producing plant species.

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Autores principales:	Bastien Christ, Chengchao Xu, Menglong Xu, Fu-Shuang Li, Naoki Wada, Andrew J. Mitchell, Xiu-Lin Han, Meng-Liang Wen, Makoto Fujita, Jing-Ke Weng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e13c38f37d8b4fb285caa3dbbf0a5a77
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spelling	oai:doaj.org-article:e13c38f37d8b4fb285caa3dbbf0a5a772021-12-02T16:58:18ZRepeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants10.1038/s41467-019-11286-72041-1723https://doaj.org/article/e13c38f37d8b4fb285caa3dbbf0a5a772019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11286-7https://doaj.org/toc/2041-1723Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical distinct diosgenin-producing plant species.Bastien ChristChengchao XuMenglong XuFu-Shuang LiNaoki WadaAndrew J. MitchellXiu-Lin HanMeng-Liang WenMakoto FujitaJing-Ke WengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bastien Christ Chengchao Xu Menglong Xu Fu-Shuang Li Naoki Wada Andrew J. Mitchell Xiu-Lin Han Meng-Liang Wen Makoto Fujita Jing-Ke Weng Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
description	Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical distinct diosgenin-producing plant species.
format	article
author	Bastien Christ Chengchao Xu Menglong Xu Fu-Shuang Li Naoki Wada Andrew J. Mitchell Xiu-Lin Han Meng-Liang Wen Makoto Fujita Jing-Ke Weng
author_facet	Bastien Christ Chengchao Xu Menglong Xu Fu-Shuang Li Naoki Wada Andrew J. Mitchell Xiu-Lin Han Meng-Liang Wen Makoto Fujita Jing-Ke Weng
author_sort	Bastien Christ
title	Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
title_short	Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
title_full	Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
title_fullStr	Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
title_full_unstemmed	Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
title_sort	repeated evolution of cytochrome p450-mediated spiroketal steroid biosynthesis in plants
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e13c38f37d8b4fb285caa3dbbf0a5a77
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Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

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