Activation and Role of Astrocytes in Ischemic Stroke

Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system (CNS). They are responsible for the homeostasis, nutrition, and protection...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xin-Ya Shen, Zhen-Kun Gao, Yu Han, Mei Yuan, Yi-Sha Guo, Xia Bi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	astrocyte oxidative stress cerebral edema glutamate inflammation blood–brain barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e13d8fe7b33b4dcb940fac284eceb6d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e13d8fe7b33b4dcb940fac284eceb6d7
record_format	dspace
spelling	oai:doaj.org-article:e13d8fe7b33b4dcb940fac284eceb6d72021-11-17T04:55:18ZActivation and Role of Astrocytes in Ischemic Stroke1662-510210.3389/fncel.2021.755955https://doaj.org/article/e13d8fe7b33b4dcb940fac284eceb6d72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.755955/fullhttps://doaj.org/toc/1662-5102Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system (CNS). They are responsible for the homeostasis, nutrition, and protection of the CNS and play an essential role in many nervous system diseases’ physiological and pathological processes. After stroke injury, astrocytes are activated and play a protective role through the heterogeneous and gradual changes of their gene expression, morphology, proliferation, and function, that is, reactive astrocytes. However, the position of reactive astrocytes has always been a controversial topic. Many studies have shown that reactive astrocytes are a double-edged sword with both beneficial and harmful effects. It is worth noting that their different spatial and temporal expression determines astrocytes’ various functions. Here, we comprehensively review the different roles and mechanisms of astrocytes after ischemic stroke. In addition, the intracellular mechanism of astrocyte activation has also been involved. More importantly, due to the complex cascade reaction and action mechanism after ischemic stroke, the role of astrocytes is still difficult to define. Still, there is no doubt that astrocytes are one of the critical factors mediating the deterioration or improvement of ischemic stroke.Xin-Ya ShenZhen-Kun GaoYu HanMei YuanYi-Sha GuoXia BiFrontiers Media S.A.articleastrocyteoxidative stresscerebral edemaglutamateinflammationblood–brain barrierNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	astrocyte oxidative stress cerebral edema glutamate inflammation blood–brain barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	astrocyte oxidative stress cerebral edema glutamate inflammation blood–brain barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xin-Ya Shen Zhen-Kun Gao Yu Han Mei Yuan Yi-Sha Guo Xia Bi Activation and Role of Astrocytes in Ischemic Stroke
description	Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant glial cells in the central nervous system (CNS). They are responsible for the homeostasis, nutrition, and protection of the CNS and play an essential role in many nervous system diseases’ physiological and pathological processes. After stroke injury, astrocytes are activated and play a protective role through the heterogeneous and gradual changes of their gene expression, morphology, proliferation, and function, that is, reactive astrocytes. However, the position of reactive astrocytes has always been a controversial topic. Many studies have shown that reactive astrocytes are a double-edged sword with both beneficial and harmful effects. It is worth noting that their different spatial and temporal expression determines astrocytes’ various functions. Here, we comprehensively review the different roles and mechanisms of astrocytes after ischemic stroke. In addition, the intracellular mechanism of astrocyte activation has also been involved. More importantly, due to the complex cascade reaction and action mechanism after ischemic stroke, the role of astrocytes is still difficult to define. Still, there is no doubt that astrocytes are one of the critical factors mediating the deterioration or improvement of ischemic stroke.
format	article
author	Xin-Ya Shen Zhen-Kun Gao Yu Han Mei Yuan Yi-Sha Guo Xia Bi
author_facet	Xin-Ya Shen Zhen-Kun Gao Yu Han Mei Yuan Yi-Sha Guo Xia Bi
author_sort	Xin-Ya Shen
title	Activation and Role of Astrocytes in Ischemic Stroke
title_short	Activation and Role of Astrocytes in Ischemic Stroke
title_full	Activation and Role of Astrocytes in Ischemic Stroke
title_fullStr	Activation and Role of Astrocytes in Ischemic Stroke
title_full_unstemmed	Activation and Role of Astrocytes in Ischemic Stroke
title_sort	activation and role of astrocytes in ischemic stroke
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e13d8fe7b33b4dcb940fac284eceb6d7
work_keys_str_mv	AT xinyashen activationandroleofastrocytesinischemicstroke AT zhenkungao activationandroleofastrocytesinischemicstroke AT yuhan activationandroleofastrocytesinischemicstroke AT meiyuan activationandroleofastrocytesinischemicstroke AT yishaguo activationandroleofastrocytesinischemicstroke AT xiabi activationandroleofastrocytesinischemicstroke
_version_	1718425958686392320

Activation and Role of Astrocytes in Ischemic Stroke

Ejemplares similares