Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line

The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyros...

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Autores principales:	Akbar Idhayadhulla, Aseer Manilal, Anis Ahamed, Saud Alarifi, Gurusamy Raman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	copper nanoparticles MCF-7 breast cancer cell cytotoxicity screening DNA fragmentation fluorescence microscopy Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/e13e947188624a3591aa01c0d2855a21
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spelling	oai:doaj.org-article:e13e947188624a3591aa01c0d2855a212021-11-11T18:37:35ZPotato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line10.3390/molecules262166651420-3049https://doaj.org/article/e13e947188624a3591aa01c0d2855a212021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6665https://doaj.org/toc/1420-3049The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyrosinase with <i>N</i>-aminoethylethanolamine to produce Cu(II)-NPs and these were characterized by means of FT-IR, UV-Spectroscopy, XRD, SEM, TEM and a particle size analyzer. These Tyr-Cu(II)-AEEA NPs were tested as anticancer agents against MCF-7 breast cancer cells. Fluorescence microscopy and DNA fragmentation were also performed, which revealed the inhibiting potentials of Cu(II)-AEEA NPs and consequent cell death; Tyr-Cu(II)-AEEA NPs show potential cytotoxicity activity and this nano material could be contemplated as an anticancer medicament in future investigations.Akbar IdhayadhullaAseer ManilalAnis AhamedSaud AlarifiGurusamy RamanMDPI AGarticlecopper nanoparticlesMCF-7 breast cancer cellcytotoxicity screeningDNA fragmentationfluorescence microscopyOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6665, p 6665 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	copper nanoparticles MCF-7 breast cancer cell cytotoxicity screening DNA fragmentation fluorescence microscopy Organic chemistry QD241-441
spellingShingle	copper nanoparticles MCF-7 breast cancer cell cytotoxicity screening DNA fragmentation fluorescence microscopy Organic chemistry QD241-441 Akbar Idhayadhulla Aseer Manilal Anis Ahamed Saud Alarifi Gurusamy Raman Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
description	The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyrosinase with <i>N</i>-aminoethylethanolamine to produce Cu(II)-NPs and these were characterized by means of FT-IR, UV-Spectroscopy, XRD, SEM, TEM and a particle size analyzer. These Tyr-Cu(II)-AEEA NPs were tested as anticancer agents against MCF-7 breast cancer cells. Fluorescence microscopy and DNA fragmentation were also performed, which revealed the inhibiting potentials of Cu(II)-AEEA NPs and consequent cell death; Tyr-Cu(II)-AEEA NPs show potential cytotoxicity activity and this nano material could be contemplated as an anticancer medicament in future investigations.
format	article
author	Akbar Idhayadhulla Aseer Manilal Anis Ahamed Saud Alarifi Gurusamy Raman
author_facet	Akbar Idhayadhulla Aseer Manilal Anis Ahamed Saud Alarifi Gurusamy Raman
author_sort	Akbar Idhayadhulla
title	Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
title_short	Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
title_full	Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
title_fullStr	Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
title_full_unstemmed	Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
title_sort	potato peels mediated synthesis of cu(ii)-nanoparticles from tyrosinase reacted with bis-(<i>n</i>-aminoethylethanolamine) (tyr-cu(ii)-aeea nps) and their cytotoxicity against michigan cancer foundation-7 breast cancer cell line
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e13e947188624a3591aa01c0d2855a21
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Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(<i>N</i>-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line

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