Modulation of anti-tumor immunity by the brain’s reward system

Neural activation can have wide ranging effects beyond central and peripheral nervous system. This work shows that chemogenetic activation of the brain’s reward system ventral tegmental area (VTA) can boost mice’s immune function, confer anti-tumor immunity, and reduce tumor mass in experimental rod...

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Autores principales:	Tamar L Ben-Shaanan, Maya Schiller, Hilla Azulay-Debby, Ben Korin, Nadia Boshnak, Tamar Koren, Maria Krot, Jivan Shakya, Michal A. Rahat, Fahed Hakim, Asya Rolls
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e141999bd3eb4b77ad6629d45a8d305d
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spelling	oai:doaj.org-article:e141999bd3eb4b77ad6629d45a8d305d2021-12-02T17:31:16ZModulation of anti-tumor immunity by the brain’s reward system10.1038/s41467-018-05283-52041-1723https://doaj.org/article/e141999bd3eb4b77ad6629d45a8d305d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05283-5https://doaj.org/toc/2041-1723Neural activation can have wide ranging effects beyond central and peripheral nervous system. This work shows that chemogenetic activation of the brain’s reward system ventral tegmental area (VTA) can boost mice’s immune function, confer anti-tumor immunity, and reduce tumor mass in experimental rodent models of lung carcinoma and melanoma.Tamar L Ben-ShaananMaya SchillerHilla Azulay-DebbyBen KorinNadia BoshnakTamar KorenMaria KrotJivan ShakyaMichal A. RahatFahed HakimAsya RollsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamar L Ben-Shaanan Maya Schiller Hilla Azulay-Debby Ben Korin Nadia Boshnak Tamar Koren Maria Krot Jivan Shakya Michal A. Rahat Fahed Hakim Asya Rolls Modulation of anti-tumor immunity by the brain’s reward system
description	Neural activation can have wide ranging effects beyond central and peripheral nervous system. This work shows that chemogenetic activation of the brain’s reward system ventral tegmental area (VTA) can boost mice’s immune function, confer anti-tumor immunity, and reduce tumor mass in experimental rodent models of lung carcinoma and melanoma.
format	article
author	Tamar L Ben-Shaanan Maya Schiller Hilla Azulay-Debby Ben Korin Nadia Boshnak Tamar Koren Maria Krot Jivan Shakya Michal A. Rahat Fahed Hakim Asya Rolls
author_facet	Tamar L Ben-Shaanan Maya Schiller Hilla Azulay-Debby Ben Korin Nadia Boshnak Tamar Koren Maria Krot Jivan Shakya Michal A. Rahat Fahed Hakim Asya Rolls
author_sort	Tamar L Ben-Shaanan
title	Modulation of anti-tumor immunity by the brain’s reward system
title_short	Modulation of anti-tumor immunity by the brain’s reward system
title_full	Modulation of anti-tumor immunity by the brain’s reward system
title_fullStr	Modulation of anti-tumor immunity by the brain’s reward system
title_full_unstemmed	Modulation of anti-tumor immunity by the brain’s reward system
title_sort	modulation of anti-tumor immunity by the brain’s reward system
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e141999bd3eb4b77ad6629d45a8d305d
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Modulation of anti-tumor immunity by the brain’s reward system

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