Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)

Accumulating evidence has revealed the anti-inflammatory effects of arbutin against various diseases. However, the effects of arbutin are not clarified in ulcerative colitis. This study was intended to investigate the protective effects and mechanisms of arbutin on DSS-induced colitis. Hematoxylin e...

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Autores principales:	Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding, Hongwen Sun
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	arbutin ulcerative colitis inflammation apoptosis jnk p38 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/e144612cfff54c6e8fcdbddb61f25445
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spelling	oai:doaj.org-article:e144612cfff54c6e8fcdbddb61f254452021-11-17T14:21:59ZArbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)2165-59792165-598710.1080/21655979.2021.2005746https://doaj.org/article/e144612cfff54c6e8fcdbddb61f254452021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2005746https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Accumulating evidence has revealed the anti-inflammatory effects of arbutin against various diseases. However, the effects of arbutin are not clarified in ulcerative colitis. This study was intended to investigate the protective effects and mechanisms of arbutin on DSS-induced colitis. Hematoxylin eosin staining was performed to determine the pathological damage of intestinal tissue in mice. Inflammatory factors levels in intestinal tissue were detected by enzyme linked immunosorbent assay (ELISA) assay. TUNEL staining showed the apoptosis levels of cells. Intestinal permeability was analyzed using the application of Fluorescein isothiocyanate Dextran (FD) 4. The levels of Zona Occludens 1 (ZO-1), occluding and claudin-1, and the related proteins in MAPK/ELK1 pathway were analyzed by Western blot. DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-α), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon. Additionally, intestinal permeability was increased and the levels of tight function-related proteins were increased following DSS induction. Its effects could be greatly improved by arbutin. Arbutin exerted effects by eliciting anti-inflammatory effects and maintaining normal intestinal mucosal barrier function, the action mechanism of which could be associated with MAPK/ELK1 pathway.Chuan ZhangHuiping ZhuHui JieHengyue DingHongwen SunTaylor & Francis Grouparticlearbutinulcerative colitisinflammationapoptosisjnkp38BiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arbutin ulcerative colitis inflammation apoptosis jnk p38 Biotechnology TP248.13-248.65
spellingShingle	arbutin ulcerative colitis inflammation apoptosis jnk p38 Biotechnology TP248.13-248.65 Chuan Zhang Huiping Zhu Hui Jie Hengyue Ding Hongwen Sun Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
description	Accumulating evidence has revealed the anti-inflammatory effects of arbutin against various diseases. However, the effects of arbutin are not clarified in ulcerative colitis. This study was intended to investigate the protective effects and mechanisms of arbutin on DSS-induced colitis. Hematoxylin eosin staining was performed to determine the pathological damage of intestinal tissue in mice. Inflammatory factors levels in intestinal tissue were detected by enzyme linked immunosorbent assay (ELISA) assay. TUNEL staining showed the apoptosis levels of cells. Intestinal permeability was analyzed using the application of Fluorescein isothiocyanate Dextran (FD) 4. The levels of Zona Occludens 1 (ZO-1), occluding and claudin-1, and the related proteins in MAPK/ELK1 pathway were analyzed by Western blot. DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-α), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon. Additionally, intestinal permeability was increased and the levels of tight function-related proteins were increased following DSS induction. Its effects could be greatly improved by arbutin. Arbutin exerted effects by eliciting anti-inflammatory effects and maintaining normal intestinal mucosal barrier function, the action mechanism of which could be associated with MAPK/ELK1 pathway.
format	article
author	Chuan Zhang Huiping Zhu Hui Jie Hengyue Ding Hongwen Sun
author_facet	Chuan Zhang Huiping Zhu Hui Jie Hengyue Ding Hongwen Sun
author_sort	Chuan Zhang
title	Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
title_short	Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
title_full	Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
title_fullStr	Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
title_full_unstemmed	Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
title_sort	arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (dss)
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/e144612cfff54c6e8fcdbddb61f25445
work_keys_str_mv	AT chuanzhang arbutinamelioratedulcerativecolitisofmiceinducedbydextransodiumsulfatedss AT huipingzhu arbutinamelioratedulcerativecolitisofmiceinducedbydextransodiumsulfatedss AT huijie arbutinamelioratedulcerativecolitisofmiceinducedbydextransodiumsulfatedss AT hengyueding arbutinamelioratedulcerativecolitisofmiceinducedbydextransodiumsulfatedss AT hongwensun arbutinamelioratedulcerativecolitisofmiceinducedbydextransodiumsulfatedss
_version_	1718425450468868096

Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)

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