Modulation of Interleukin-12 activity in the presence of heparin
Abstract Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine the mechanism(s) by which heparin influences IL-12 b...
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Auteurs principaux: | Srinivas Jayanthi, Bhanu prasanth Koppolu, Khue G. Nguyen, Sean G. Smith, Barbara K. Felber, Thallapuranam Krishnaswamy Suresh Kumar, David A. Zaharoff |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
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Accès en ligne: | https://doaj.org/article/e144fa0271714f01b788c20adf60ba9f |
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