Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer

Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer

Abstract Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach the threshold for survival and lead to cell death. There is a fundamental gap in knowledge on the molecu...

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Autores principales: Patricia Dauer, Vineet K. Gupta, Olivia McGinn, Alice Nomura, Nikita S. Sharma, Nivedita Arora, Bhuwan Giri, Vikas Dudeja, Ashok K. Saluja, Sulagna Banerjee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e14646c77c0341be9bc1d51784fe5589
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