Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat

Jin-hong Han,1,2 Hong-zhao Tian,2 Yang-yang Lian,1 Yi Yu,1 Cheng-biao Lu,2 Xin-min Li,3 Rui-ling Zhang,1 Haiyun Xu4 1The Second Affiliated Hospital of Xinxiang Medical University, 2School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, People’s Republic of China; 3Departm...

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Autores principales:	Han JH, Tian HZ, Lian YY, Yu Y, Lu CB, Li XM, Zhang RL, Xu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e148e29c9eb245dfbf153bdcfe5fa6a2
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spelling	oai:doaj.org-article:e148e29c9eb245dfbf153bdcfe5fa6a22021-12-02T02:44:15ZQuetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat1178-2021https://doaj.org/article/e148e29c9eb245dfbf153bdcfe5fa6a22015-06-01T00:00:00Zhttp://www.dovepress.com/quetiapine-mitigates-the-ethanol-induced-oxidative-stress-in-brain-tis-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jin-hong Han,1,2 Hong-zhao Tian,2 Yang-yang Lian,1 Yi Yu,1 Cheng-biao Lu,2 Xin-min Li,3 Rui-ling Zhang,1 Haiyun Xu4 1The Second Affiliated Hospital of Xinxiang Medical University, 2School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, People’s Republic of China; 3Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 4The Mental Health Center, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China Abstract: Quetiapine, an atypical antipsychotic, has been employed to treat alcoholic patients with comorbid psychopathology. It was shown to scavenge hydroxyl radicals and to protect cultured cells from noxious effects of oxidative stress, a pathophysiological mechanism involved in the toxicity of alcohol. This study compared the redox status of the liver and the brain regions of prefrontal cortex, hippocampus, and cerebellum of rats treated with or without ethanol and quetiapine. Ethanol administration for 1 week induced oxidative stress in the liver and decreased the activity of glutathione peroxidase and total antioxidant capacity (TAC) there. Coadministration of quetiapine did not protect glutathione peroxidase and TAC in the liver against the noxious effect of ethanol, thus was unable to mitigate the ethanol-induced oxidative stress there. The ethanol-induced alteration in the redox status in the prefrontal cortex is mild, whereas the hippocampus and cerebellum are more susceptible to ethanol intoxication. For all the examined brain regions, coadministration of quetiapine exerted effective protection on the antioxidants catalase and total superoxide dismutase and on the TAC, thus completely blocking the ethanol-induced oxidative stress in these brain regions. These protective effects may explain the clinical observations that quetiapine reduced psychiatric symptoms intensity and maintained a good level of tolerability in chronic alcoholism with comorbid psychopathology. Keywords: ethanol, quetiapine, oxidative stress, antioxidant Han JHTian HZLian YYYu YLu CBLi XMZhang RLXu HDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1473-1482 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Han JH Tian HZ Lian YY Yu Y Lu CB Li XM Zhang RL Xu H Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
description	Jin-hong Han,1,2 Hong-zhao Tian,2 Yang-yang Lian,1 Yi Yu,1 Cheng-biao Lu,2 Xin-min Li,3 Rui-ling Zhang,1 Haiyun Xu4 1The Second Affiliated Hospital of Xinxiang Medical University, 2School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, People’s Republic of China; 3Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 4The Mental Health Center, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China Abstract: Quetiapine, an atypical antipsychotic, has been employed to treat alcoholic patients with comorbid psychopathology. It was shown to scavenge hydroxyl radicals and to protect cultured cells from noxious effects of oxidative stress, a pathophysiological mechanism involved in the toxicity of alcohol. This study compared the redox status of the liver and the brain regions of prefrontal cortex, hippocampus, and cerebellum of rats treated with or without ethanol and quetiapine. Ethanol administration for 1 week induced oxidative stress in the liver and decreased the activity of glutathione peroxidase and total antioxidant capacity (TAC) there. Coadministration of quetiapine did not protect glutathione peroxidase and TAC in the liver against the noxious effect of ethanol, thus was unable to mitigate the ethanol-induced oxidative stress there. The ethanol-induced alteration in the redox status in the prefrontal cortex is mild, whereas the hippocampus and cerebellum are more susceptible to ethanol intoxication. For all the examined brain regions, coadministration of quetiapine exerted effective protection on the antioxidants catalase and total superoxide dismutase and on the TAC, thus completely blocking the ethanol-induced oxidative stress in these brain regions. These protective effects may explain the clinical observations that quetiapine reduced psychiatric symptoms intensity and maintained a good level of tolerability in chronic alcoholism with comorbid psychopathology. Keywords: ethanol, quetiapine, oxidative stress, antioxidant
format	article
author	Han JH Tian HZ Lian YY Yu Y Lu CB Li XM Zhang RL Xu H
author_facet	Han JH Tian HZ Lian YY Yu Y Lu CB Li XM Zhang RL Xu H
author_sort	Han JH
title	Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
title_short	Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
title_full	Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
title_fullStr	Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
title_full_unstemmed	Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
title_sort	quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e148e29c9eb245dfbf153bdcfe5fa6a2
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Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat

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