Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS

Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS). This paper presents a set of equations as a model to describe the interactions betw...

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Autores principales:	Osman Taylan, Mona Abusurrah, Ehsan Eftekhari-Zadeh, Ehsan Nazemi, Farheen Bano, Ali Roshani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuron astrocyte tripartite synapse Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/e14acb9991aa435f8635061c2073d72d
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spelling	oai:doaj.org-article:e14acb9991aa435f8635061c2073d72d2021-11-11T18:15:46ZControlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS10.3390/math92127002227-7390https://doaj.org/article/e14acb9991aa435f8635061c2073d72d2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-7390/9/21/2700https://doaj.org/toc/2227-7390Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS). This paper presents a set of equations as a model to describe the interactions between neurons and astrocyte. A VHDL–AMS-based tripartite synapse model that includes a pre-synaptic neuron, the synaptic terminal, a post-synaptic neuron, and an astrocyte cell is presented. In this model, the astrocyte acts as a controller module for neurons and can regulates the spiking activity of them. Simulation results show that by regulating the coupling coefficients of astrocytes, spiking frequency of neurons can be reduced and the activity of neuronal cells is modulated.Osman TaylanMona AbusurrahEhsan Eftekhari-ZadehEhsan NazemiFarheen BanoAli RoshaniMDPI AGarticleneuronastrocytetripartite synapseMathematicsQA1-939ENMathematics, Vol 9, Iss 2700, p 2700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuron astrocyte tripartite synapse Mathematics QA1-939
spellingShingle	neuron astrocyte tripartite synapse Mathematics QA1-939 Osman Taylan Mona Abusurrah Ehsan Eftekhari-Zadeh Ehsan Nazemi Farheen Bano Ali Roshani Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
description	Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS). This paper presents a set of equations as a model to describe the interactions between neurons and astrocyte. A VHDL–AMS-based tripartite synapse model that includes a pre-synaptic neuron, the synaptic terminal, a post-synaptic neuron, and an astrocyte cell is presented. In this model, the astrocyte acts as a controller module for neurons and can regulates the spiking activity of them. Simulation results show that by regulating the coupling coefficients of astrocytes, spiking frequency of neurons can be reduced and the activity of neuronal cells is modulated.
format	article
author	Osman Taylan Mona Abusurrah Ehsan Eftekhari-Zadeh Ehsan Nazemi Farheen Bano Ali Roshani
author_facet	Osman Taylan Mona Abusurrah Ehsan Eftekhari-Zadeh Ehsan Nazemi Farheen Bano Ali Roshani
author_sort	Osman Taylan
title	Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
title_short	Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
title_full	Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
title_fullStr	Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
title_full_unstemmed	Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS
title_sort	controlling effects of astrocyte on neuron behavior in tripartite synapse using vhdl–ams
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e14acb9991aa435f8635061c2073d72d
work_keys_str_mv	AT osmantaylan controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams AT monaabusurrah controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams AT ehsaneftekharizadeh controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams AT ehsannazemi controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams AT farheenbano controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams AT aliroshani controllingeffectsofastrocyteonneuronbehaviorintripartitesynapseusingvhdlams
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Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS

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