Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade. Both can eventually trigger thrombosis and inflammation. Therefore, understanding these initial responses of the body is of great importance for newly...

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Autores principales:	Anne Strohbach, Raila Busch
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomaterial blood compatibility complement activation coagulation in vitro testing Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e14acfa862ee48f4878e771590ec3de5
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spelling	oai:doaj.org-article:e14acfa862ee48f4878e771590ec3de52021-11-11T16:51:52ZPredicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions10.3390/ijms2221113901422-00671661-6596https://doaj.org/article/e14acfa862ee48f4878e771590ec3de52021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11390https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade. Both can eventually trigger thrombosis and inflammation. Therefore, understanding these initial responses of the body is of great importance for newly developed biomaterials. Subtle modulation of the associated biological processes could optimize clinical outcomes. However, our failure to produce truly blood compatible materials may reflect our inability to properly understand the mechanisms of thrombosis and inflammation associated with biomaterials. In vitro models mimicking these processes provide valuable insights into the mechanisms of biomaterial-induced complement activation and coagulation. Here, we review (i) the influence of biomaterials on complement and coagulation cascades, (ii) the significance of complement-coagulation interactions for the clinical success of cardiovascular implants, (iii) the modulation of complement activation by surface modifications, and (iv) in vitro testing strategies.Anne StrohbachRaila BuschMDPI AGarticlebiomaterialblood compatibilitycomplement activationcoagulationin vitro testingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11390, p 11390 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterial blood compatibility complement activation coagulation in vitro testing Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biomaterial blood compatibility complement activation coagulation in vitro testing Biology (General) QH301-705.5 Chemistry QD1-999 Anne Strohbach Raila Busch Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
description	The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade. Both can eventually trigger thrombosis and inflammation. Therefore, understanding these initial responses of the body is of great importance for newly developed biomaterials. Subtle modulation of the associated biological processes could optimize clinical outcomes. However, our failure to produce truly blood compatible materials may reflect our inability to properly understand the mechanisms of thrombosis and inflammation associated with biomaterials. In vitro models mimicking these processes provide valuable insights into the mechanisms of biomaterial-induced complement activation and coagulation. Here, we review (i) the influence of biomaterials on complement and coagulation cascades, (ii) the significance of complement-coagulation interactions for the clinical success of cardiovascular implants, (iii) the modulation of complement activation by surface modifications, and (iv) in vitro testing strategies.
format	article
author	Anne Strohbach Raila Busch
author_facet	Anne Strohbach Raila Busch
author_sort	Anne Strohbach
title	Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
title_short	Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
title_full	Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
title_fullStr	Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
title_full_unstemmed	Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions
title_sort	predicting the in vivo performance of cardiovascular biomaterials: current approaches in vitro evaluation of blood-biomaterial interactions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e14acfa862ee48f4878e771590ec3de5
work_keys_str_mv	AT annestrohbach predictingtheinvivoperformanceofcardiovascularbiomaterialscurrentapproachesinvitroevaluationofbloodbiomaterialinteractions AT railabusch predictingtheinvivoperformanceofcardiovascularbiomaterialscurrentapproachesinvitroevaluationofbloodbiomaterialinteractions
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Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

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