Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study

A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a s...

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Autores principales:	Ioanna Yiannakou, Martha R. Singer, Paul F. Jacques, Vanessa Xanthakis, R. Curtis Ellison, Lynn L. Moore
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer Mediterranean diet diet patterns cohort study epidemiology Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e14e4642718049a48fd12ddcdc9e4b67
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spelling	oai:doaj.org-article:e14e4642718049a48fd12ddcdc9e4b672021-11-25T18:36:29ZAdherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study10.3390/nu131140642072-6643https://doaj.org/article/e14e4642718049a48fd12ddcdc9e4b672021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4064https://doaj.org/toc/2072-6643A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire at exam 5 (1991–1995). Subjects included 2966 participants of the Framingham Offspring Study who were free of prevalent cancer. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, and anthropometric measures. Cox-models were also used to examine effect modification by lifestyle and anthropometric measures. During 18 years of median follow-up, 259 women and 352 men were diagnosed with cancer. Women with moderate or higher adherence to the MSDP had ≥25% lower risks of cancer than women with the lowest MSDP (HR (moderate vs. lowest): 0.71, 95% CI: 0.52–0.97 and HR (highest vs. lowest): 0.74; 95% CI: 0.55–0.99). The association between MSDP score and cancer risk in men was weaker except in non-smokers. Beneficial effects of the MSDP in women were stronger among those who were not overweight. In this study, higher adherence to MSDP was associated with lower cancer risk, especially among women.Ioanna YiannakouMartha R. SingerPaul F. JacquesVanessa XanthakisR. Curtis EllisonLynn L. MooreMDPI AGarticlecancerMediterranean dietdiet patternscohort studyepidemiologyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4064, p 4064 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer Mediterranean diet diet patterns cohort study epidemiology Nutrition. Foods and food supply TX341-641
spellingShingle	cancer Mediterranean diet diet patterns cohort study epidemiology Nutrition. Foods and food supply TX341-641 Ioanna Yiannakou Martha R. Singer Paul F. Jacques Vanessa Xanthakis R. Curtis Ellison Lynn L. Moore Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
description	A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire at exam 5 (1991–1995). Subjects included 2966 participants of the Framingham Offspring Study who were free of prevalent cancer. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, and anthropometric measures. Cox-models were also used to examine effect modification by lifestyle and anthropometric measures. During 18 years of median follow-up, 259 women and 352 men were diagnosed with cancer. Women with moderate or higher adherence to the MSDP had ≥25% lower risks of cancer than women with the lowest MSDP (HR (moderate vs. lowest): 0.71, 95% CI: 0.52–0.97 and HR (highest vs. lowest): 0.74; 95% CI: 0.55–0.99). The association between MSDP score and cancer risk in men was weaker except in non-smokers. Beneficial effects of the MSDP in women were stronger among those who were not overweight. In this study, higher adherence to MSDP was associated with lower cancer risk, especially among women.
format	article
author	Ioanna Yiannakou Martha R. Singer Paul F. Jacques Vanessa Xanthakis R. Curtis Ellison Lynn L. Moore
author_facet	Ioanna Yiannakou Martha R. Singer Paul F. Jacques Vanessa Xanthakis R. Curtis Ellison Lynn L. Moore
author_sort	Ioanna Yiannakou
title	Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
title_short	Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
title_full	Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
title_fullStr	Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
title_full_unstemmed	Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study
title_sort	adherence to a mediterranean-style dietary pattern and cancer risk in a prospective cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e14e4642718049a48fd12ddcdc9e4b67
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Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study

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