Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell response to a hepatitis B virus epitope by amplifying...

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Autores principales:	Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, Nicholas R. J. Gascoigne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1513454279048d48870135ba8d4a18d
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spelling	oai:doaj.org-article:e1513454279048d48870135ba8d4a18d2021-12-02T16:49:38ZNonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling10.1038/s41467-018-05288-02041-1723https://doaj.org/article/e1513454279048d48870135ba8d4a18d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05288-0https://doaj.org/toc/2041-1723Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell response to a hepatitis B virus epitope by amplifying T-cell receptor signals.Xiang ZhaoShvetha SankaranJiawei YapChien Tei TooZi Zong HoGarry DoltonMateusz LegutEe Chee RenAndrew K. SewellAntonio BertolettiPaul A. MacAryJoanna BrzostekNicholas R. J. GascoigneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiang Zhao Shvetha Sankaran Jiawei Yap Chien Tei Too Zi Zong Ho Garry Dolton Mateusz Legut Ee Chee Ren Andrew K. Sewell Antonio Bertoletti Paul A. MacAry Joanna Brzostek Nicholas R. J. Gascoigne Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
description	Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell response to a hepatitis B virus epitope by amplifying T-cell receptor signals.
format	article
author	Xiang Zhao Shvetha Sankaran Jiawei Yap Chien Tei Too Zi Zong Ho Garry Dolton Mateusz Legut Ee Chee Ren Andrew K. Sewell Antonio Bertoletti Paul A. MacAry Joanna Brzostek Nicholas R. J. Gascoigne
author_facet	Xiang Zhao Shvetha Sankaran Jiawei Yap Chien Tei Too Zi Zong Ho Garry Dolton Mateusz Legut Ee Chee Ren Andrew K. Sewell Antonio Bertoletti Paul A. MacAry Joanna Brzostek Nicholas R. J. Gascoigne
author_sort	Xiang Zhao
title	Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
title_short	Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
title_full	Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
title_fullStr	Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
title_full_unstemmed	Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
title_sort	nonstimulatory peptide–mhc enhances human t-cell antigen-specific responses by amplifying proximal tcr signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e1513454279048d48870135ba8d4a18d
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Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

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