Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell response to a hepatitis B virus epitope by amplifying...

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Autores principales: Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, Nicholas R. J. Gascoigne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/e1513454279048d48870135ba8d4a18d
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