Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study

Background: Patients with short bowel syndrome (SBS) are at a high risk of cholestasis or cholelithiasis. This study aimed to determine the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended period.Methods: All eligible adults diagnosed with SBS...

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Autores principales:	Xuejin Gao, Li Zhang, Siwen Wang, Yaqin Xiao, Deshuai Song, Da Zhou, Xinying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cholelithiasis short bowel syndrome prevalence risk factors clinical consequence Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e152ed358c80420f9a5cb8de8237e76d
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spelling	oai:doaj.org-article:e152ed358c80420f9a5cb8de8237e76d2021-12-01T13:58:48ZPrevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study2296-861X10.3389/fnut.2021.762240https://doaj.org/article/e152ed358c80420f9a5cb8de8237e76d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.762240/fullhttps://doaj.org/toc/2296-861XBackground: Patients with short bowel syndrome (SBS) are at a high risk of cholestasis or cholelithiasis. This study aimed to determine the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended period.Methods: All eligible adults diagnosed with SBS and admitted to a tertiary hospital center between January 2010 and December 2019 were retrospectively identified from the hospital records database. Kaplan–Meier analysis was used to estimate the cumulative incidence of SBS during the 10-year period. For assessment the risk factors for cholelithiasis, we used multivariate Cox proportional hazards model with estimation of hazard ratio (HR) with 95% confidence intervals (95 %CI).Results: This study enrolled 345 eligible patients with SBS. Kaplan–Meier analysis revealed that 72 patients (20.9%) developed cholelithiasis during the 10-year observation period. In multivariate analyses using the Cox proportional hazard model revealed that the remnant jejunum (HR = 2.163; 95% confidence interval [CI]: 1.156–4.047, p = 0.016) and parenteral nutrition dependence (HR = 1.783; 95% CI: 1.077–2.952, p = 0.025) were independent risk factors for cholelithiasis in adults with SBS. Twenty-eight patients developed symptoms and/or complications in the cholelithiasis group. Proportions of acute cholecystitis or cholangitis and acute pancreatitis were significantly increased in the cholelithiasis group compared with the non-cholelithiasis group (31.9 vs. 7.7%, p < 0.01; and 6.9 vs. 1.1%, p = 0.003, respectively).Conclusion: Because of the adverse clinical consequences of cholelithiasis, adult patients with SBS should be closely monitored, and preventive interventions should be considered.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04867538.Xuejin GaoLi ZhangSiwen WangSiwen WangYaqin XiaoYaqin XiaoDeshuai SongDeshuai SongDa ZhouXinying WangXinying WangXinying WangFrontiers Media S.A.articlecholelithiasisshort bowel syndromeprevalencerisk factorsclinical consequenceNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholelithiasis short bowel syndrome prevalence risk factors clinical consequence Nutrition. Foods and food supply TX341-641
spellingShingle	cholelithiasis short bowel syndrome prevalence risk factors clinical consequence Nutrition. Foods and food supply TX341-641 Xuejin Gao Li Zhang Siwen Wang Siwen Wang Yaqin Xiao Yaqin Xiao Deshuai Song Deshuai Song Da Zhou Xinying Wang Xinying Wang Xinying Wang Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
description	Background: Patients with short bowel syndrome (SBS) are at a high risk of cholestasis or cholelithiasis. This study aimed to determine the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended period.Methods: All eligible adults diagnosed with SBS and admitted to a tertiary hospital center between January 2010 and December 2019 were retrospectively identified from the hospital records database. Kaplan–Meier analysis was used to estimate the cumulative incidence of SBS during the 10-year period. For assessment the risk factors for cholelithiasis, we used multivariate Cox proportional hazards model with estimation of hazard ratio (HR) with 95% confidence intervals (95 %CI).Results: This study enrolled 345 eligible patients with SBS. Kaplan–Meier analysis revealed that 72 patients (20.9%) developed cholelithiasis during the 10-year observation period. In multivariate analyses using the Cox proportional hazard model revealed that the remnant jejunum (HR = 2.163; 95% confidence interval [CI]: 1.156–4.047, p = 0.016) and parenteral nutrition dependence (HR = 1.783; 95% CI: 1.077–2.952, p = 0.025) were independent risk factors for cholelithiasis in adults with SBS. Twenty-eight patients developed symptoms and/or complications in the cholelithiasis group. Proportions of acute cholecystitis or cholangitis and acute pancreatitis were significantly increased in the cholelithiasis group compared with the non-cholelithiasis group (31.9 vs. 7.7%, p < 0.01; and 6.9 vs. 1.1%, p = 0.003, respectively).Conclusion: Because of the adverse clinical consequences of cholelithiasis, adult patients with SBS should be closely monitored, and preventive interventions should be considered.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04867538.
format	article
author	Xuejin Gao Li Zhang Siwen Wang Siwen Wang Yaqin Xiao Yaqin Xiao Deshuai Song Deshuai Song Da Zhou Xinying Wang Xinying Wang Xinying Wang
author_facet	Xuejin Gao Li Zhang Siwen Wang Siwen Wang Yaqin Xiao Yaqin Xiao Deshuai Song Deshuai Song Da Zhou Xinying Wang Xinying Wang Xinying Wang
author_sort	Xuejin Gao
title	Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
title_short	Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
title_full	Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
title_fullStr	Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
title_full_unstemmed	Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study
title_sort	prevalence, risk factors, and complications of cholelithiasis in adults with short bowel syndrome: a longitudinal cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e152ed358c80420f9a5cb8de8237e76d
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Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study

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