Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI

Abstract The purposes of this study were (1) to characterize embryonic eye development during incubation in ovo and (2) to analyze the putative influence of repetitive ultrahigh-field MRI (UHF-MRI) measurements on this development. A population of 38 fertilized chicken eggs was divided into two sub-...

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Autores principales:	Tobias Lindner, Ronja Klose, Felix Streckenbach, Thomas Stahnke, Stefan Hadlich, Jens-Peter Kühn, Rudolf F. Guthoff, Andreas Wree, Anne-Marie Neumann, Marcus Frank, Änne Glass, Sönke Langner, Oliver Stachs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e158f1cae0e64c4ca6e34ebb82f7d99b
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spelling	oai:doaj.org-article:e158f1cae0e64c4ca6e34ebb82f7d99b2021-12-02T15:06:06ZMorphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI10.1038/s41598-017-02755-42045-2322https://doaj.org/article/e158f1cae0e64c4ca6e34ebb82f7d99b2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02755-4https://doaj.org/toc/2045-2322Abstract The purposes of this study were (1) to characterize embryonic eye development during incubation in ovo and (2) to analyze the putative influence of repetitive ultrahigh-field MRI (UHF-MRI) measurements on this development. A population of 38 fertilized chicken eggs was divided into two sub-groups: two eggs (Group A) were examined repeatedly during the developmental period from embryonic day 1 (E1) to embryonic day 20 (E20) to evaluate the influence of daily MRI scanning. A second larger group of 36 eggs was examined pairwise on one day only, from E3 to E20, and the embryos were sacrificed immediately after MR imaging (Group B). Fast T2-weighted MR sequences provided biometric data on the eye with an in-plane resolution of 74 μm. The data show rapid growth of the eye with a steep increase in intraocular dimensions in all axis directions and in eyeball volume during initial development up to E10, followed by a phase of reduced growth rate in later developmental stages. Comparison of the two groups revealed no differences in ocular development.Tobias LindnerRonja KloseFelix StreckenbachThomas StahnkeStefan HadlichJens-Peter KühnRudolf F. GuthoffAndreas WreeAnne-Marie NeumannMarcus FrankÄnne GlassSönke LangnerOliver StachsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tobias Lindner Ronja Klose Felix Streckenbach Thomas Stahnke Stefan Hadlich Jens-Peter Kühn Rudolf F. Guthoff Andreas Wree Anne-Marie Neumann Marcus Frank Änne Glass Sönke Langner Oliver Stachs Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
description	Abstract The purposes of this study were (1) to characterize embryonic eye development during incubation in ovo and (2) to analyze the putative influence of repetitive ultrahigh-field MRI (UHF-MRI) measurements on this development. A population of 38 fertilized chicken eggs was divided into two sub-groups: two eggs (Group A) were examined repeatedly during the developmental period from embryonic day 1 (E1) to embryonic day 20 (E20) to evaluate the influence of daily MRI scanning. A second larger group of 36 eggs was examined pairwise on one day only, from E3 to E20, and the embryos were sacrificed immediately after MR imaging (Group B). Fast T2-weighted MR sequences provided biometric data on the eye with an in-plane resolution of 74 μm. The data show rapid growth of the eye with a steep increase in intraocular dimensions in all axis directions and in eyeball volume during initial development up to E10, followed by a phase of reduced growth rate in later developmental stages. Comparison of the two groups revealed no differences in ocular development.
format	article
author	Tobias Lindner Ronja Klose Felix Streckenbach Thomas Stahnke Stefan Hadlich Jens-Peter Kühn Rudolf F. Guthoff Andreas Wree Anne-Marie Neumann Marcus Frank Änne Glass Sönke Langner Oliver Stachs
author_facet	Tobias Lindner Ronja Klose Felix Streckenbach Thomas Stahnke Stefan Hadlich Jens-Peter Kühn Rudolf F. Guthoff Andreas Wree Anne-Marie Neumann Marcus Frank Änne Glass Sönke Langner Oliver Stachs
author_sort	Tobias Lindner
title	Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
title_short	Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
title_full	Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
title_fullStr	Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
title_full_unstemmed	Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
title_sort	morphologic and biometric evaluation of chick embryo eyes in ovo using 7 tesla mri
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e158f1cae0e64c4ca6e34ebb82f7d99b
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Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI

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