MAIT cells contribute to protection against lethal influenza infection in vivo

MAIT cells contribute to protection against lethal influenza infection in vivo

MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenz...

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Autores principales: Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D’Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading, Alexandra J. Corbett, James McCluskey, Paul Klenerman, Katherine Kedzierska, Timothy S. C. Hinks
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/e15ac8dd044648a69319eb56458d539f
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Sumario:MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection.

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