Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study

Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is assoc...

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Autores principales:	Ifteni P, Teodorescu A, Moga MA, Pascu AM, Miclaus RS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	clozapine bipolar disorder relapse switch cost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e15bc056634b47188695294f8eadf75d
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spelling	oai:doaj.org-article:e15bc056634b47188695294f8eadf75d2021-12-02T04:55:31ZSwitching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study1178-2021https://doaj.org/article/e15bc056634b47188695294f8eadf75d2017-01-01T00:00:00Zhttps://www.dovepress.com/switching-bipolar-disorder-patients-treated-with-clozapine-to-another--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is associated with periodic symptom exacerbations, leading to functional impairment, and increased risk of suicide. Although clozapine has never been approved for the treatment of BD, it is occasionally used in severe mania. The aim of the study is to evaluate the risks and benefits of switching clozapine in remitted BD patients. This is an observational, mirror image study of 62 consecutive remitted BD outpatients treated with clozapine. Twenty-five patients were switched to another antipsychotic following a change in a drug reimbursement rule, while 37 continued on clozapine. The mean time in remission was shorter for the switched group (9.2±4 months vs 13±6 months, P=0.018), and the number of patients who relapsed was larger (n=21 vs n=8, P<0.0001). The results suggest that switching from clozapine to another antipsychotic may increase the risk of relapses in remitted patients with BD. Keywords: clozapine, bipolar disorder, relapse, switch, costIfteni PTeodorescu AMoga MAPascu AMMiclaus RSDove Medical Pressarticleclozapinebipolar disorderrelapseswitchcostNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 201-204 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	clozapine bipolar disorder relapse switch cost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	clozapine bipolar disorder relapse switch cost Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
description	Petru Ifteni,1,2 Andreea Teodorescu,1,2 Marius Alexandru Moga,1 Alina Mihaela Pascu,1 Roxana Steliana Miclaus1,2 1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania; 2Clinical Hospital of Psychiatry and Neurology Brasov, Brasov, Romania Abstract: Bipolar disorder (BD) is associated with periodic symptom exacerbations, leading to functional impairment, and increased risk of suicide. Although clozapine has never been approved for the treatment of BD, it is occasionally used in severe mania. The aim of the study is to evaluate the risks and benefits of switching clozapine in remitted BD patients. This is an observational, mirror image study of 62 consecutive remitted BD outpatients treated with clozapine. Twenty-five patients were switched to another antipsychotic following a change in a drug reimbursement rule, while 37 continued on clozapine. The mean time in remission was shorter for the switched group (9.2±4 months vs 13±6 months, P=0.018), and the number of patients who relapsed was larger (n=21 vs n=8, P<0.0001). The results suggest that switching from clozapine to another antipsychotic may increase the risk of relapses in remitted patients with BD. Keywords: clozapine, bipolar disorder, relapse, switch, cost
format	article
author	Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS
author_facet	Ifteni P Teodorescu A Moga MA Pascu AM Miclaus RS
author_sort	Ifteni P
title	Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
title_short	Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
title_full	Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
title_fullStr	Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
title_full_unstemmed	Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
title_sort	switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e15bc056634b47188695294f8eadf75d
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Switching bipolar disorder patients treated with clozapine to another antipsychotic medication: a mirror image study

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