Kinematic changes in goal-directed movements in a fear-conditioning paradigm

Abstract In individuals with a musculoskeletal disorder, goal-directed reaching movements of the hand are distorted. Here, we investigated a pain-related fear-conditioning effect on motor control. Twenty healthy participants (11 women and 9 men, 21.7 ± 2.7 years) performed a hand-reaching movement t...

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Autores principales:	Yuki Nishi, Michihiro Osumi, Masahiko Sumitani, Arito Yozu, Shu Morioka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e15c2e40d13940df956a42442a0960d7
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spelling	oai:doaj.org-article:e15c2e40d13940df956a42442a0960d72021-12-02T15:00:51ZKinematic changes in goal-directed movements in a fear-conditioning paradigm10.1038/s41598-021-90518-72045-2322https://doaj.org/article/e15c2e40d13940df956a42442a0960d72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90518-7https://doaj.org/toc/2045-2322Abstract In individuals with a musculoskeletal disorder, goal-directed reaching movements of the hand are distorted. Here, we investigated a pain-related fear-conditioning effect on motor control. Twenty healthy participants (11 women and 9 men, 21.7 ± 2.7 years) performed a hand-reaching movement task. In the acquisition phase, a painful electrocutaneous stimulus was applied on the reaching hand simultaneous with the completion of reaching. In the subsequent extinction phase, the task context was the same but the painful stimulus was omitted. We divided the kinematic data of the hand-reaching movements into acceleration and deceleration periods based on the movement-velocity characteristics, and the duration of each period indicated the degree of impairment in the feedforward and feedback motor controls. We assessed the wavelet coherence between electromyograms of the triceps and biceps brachii muscles. In the acquisition phase, the durations of painful movements were significantly longer in both the acceleration and deceleration periods. In the extinction phase, painful movements were longer only in the acceleration period and higher pain expectation and fear were maintained. Similarly, the wavelet coherence of muscles in both periods were decreased in both the acquisition and extinction phases. These results indicate that negative emotional modulations might explain the altered motor functions observed in pain patients.Yuki NishiMichihiro OsumiMasahiko SumitaniArito YozuShu MoriokaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuki Nishi Michihiro Osumi Masahiko Sumitani Arito Yozu Shu Morioka Kinematic changes in goal-directed movements in a fear-conditioning paradigm
description	Abstract In individuals with a musculoskeletal disorder, goal-directed reaching movements of the hand are distorted. Here, we investigated a pain-related fear-conditioning effect on motor control. Twenty healthy participants (11 women and 9 men, 21.7 ± 2.7 years) performed a hand-reaching movement task. In the acquisition phase, a painful electrocutaneous stimulus was applied on the reaching hand simultaneous with the completion of reaching. In the subsequent extinction phase, the task context was the same but the painful stimulus was omitted. We divided the kinematic data of the hand-reaching movements into acceleration and deceleration periods based on the movement-velocity characteristics, and the duration of each period indicated the degree of impairment in the feedforward and feedback motor controls. We assessed the wavelet coherence between electromyograms of the triceps and biceps brachii muscles. In the acquisition phase, the durations of painful movements were significantly longer in both the acceleration and deceleration periods. In the extinction phase, painful movements were longer only in the acceleration period and higher pain expectation and fear were maintained. Similarly, the wavelet coherence of muscles in both periods were decreased in both the acquisition and extinction phases. These results indicate that negative emotional modulations might explain the altered motor functions observed in pain patients.
format	article
author	Yuki Nishi Michihiro Osumi Masahiko Sumitani Arito Yozu Shu Morioka
author_facet	Yuki Nishi Michihiro Osumi Masahiko Sumitani Arito Yozu Shu Morioka
author_sort	Yuki Nishi
title	Kinematic changes in goal-directed movements in a fear-conditioning paradigm
title_short	Kinematic changes in goal-directed movements in a fear-conditioning paradigm
title_full	Kinematic changes in goal-directed movements in a fear-conditioning paradigm
title_fullStr	Kinematic changes in goal-directed movements in a fear-conditioning paradigm
title_full_unstemmed	Kinematic changes in goal-directed movements in a fear-conditioning paradigm
title_sort	kinematic changes in goal-directed movements in a fear-conditioning paradigm
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e15c2e40d13940df956a42442a0960d7
work_keys_str_mv	AT yukinishi kinematicchangesingoaldirectedmovementsinafearconditioningparadigm AT michihiroosumi kinematicchangesingoaldirectedmovementsinafearconditioningparadigm AT masahikosumitani kinematicchangesingoaldirectedmovementsinafearconditioningparadigm AT aritoyozu kinematicchangesingoaldirectedmovementsinafearconditioningparadigm AT shumorioka kinematicchangesingoaldirectedmovementsinafearconditioningparadigm
_version_	1718389170082152448

Kinematic changes in goal-directed movements in a fear-conditioning paradigm

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