Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Shannon L. Wolfman, Daniel F. Gill, Fili Bogdanic, Katie Long, Ream Al-Hasani, Jordan G. McCall, Michael R. Bruchas, Daniel S. McGehee
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e15d944c114d4cb58850d8356381d660
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:e15d944c114d4cb58850d8356381d660
record_format	dspace
spelling	oai:doaj.org-article:e15d944c114d4cb58850d8356381d6602021-12-02T17:32:32ZNicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum10.1038/s41467-018-04654-22041-1723https://doaj.org/article/e15d944c114d4cb58850d8356381d6602018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04654-2https://doaj.org/toc/2041-1723Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.Shannon L. WolfmanDaniel F. GillFili BogdanicKatie LongReam Al-HasaniJordan G. McCallMichael R. BruchasDaniel S. McGeheeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
description	Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.
format	article
author	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
author_facet	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
author_sort	Shannon L. Wolfman
title	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_short	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_fullStr	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full_unstemmed	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_sort	nicotine aversion is mediated by gabaergic interpeduncular nucleus inputs to laterodorsal tegmentum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e15d944c114d4cb58850d8356381d660
work_keys_str_mv	AT shannonlwolfman nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT danielfgill nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT filibogdanic nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT katielong nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT reamalhasani nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT jordangmccall nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT michaelrbruchas nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum AT danielsmcgehee nicotineaversionismediatedbygabaergicinterpeduncularnucleusinputstolaterodorsaltegmentum
_version_	1718380280788549632

Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

Documents similaires