Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.

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Autores principales:	Shannon L. Wolfman, Daniel F. Gill, Fili Bogdanic, Katie Long, Ream Al-Hasani, Jordan G. McCall, Michael R. Bruchas, Daniel S. McGehee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e15d944c114d4cb58850d8356381d660
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spelling	oai:doaj.org-article:e15d944c114d4cb58850d8356381d6602021-12-02T17:32:32ZNicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum10.1038/s41467-018-04654-22041-1723https://doaj.org/article/e15d944c114d4cb58850d8356381d6602018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04654-2https://doaj.org/toc/2041-1723Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.Shannon L. WolfmanDaniel F. GillFili BogdanicKatie LongReam Al-HasaniJordan G. McCallMichael R. BruchasDaniel S. McGeheeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
description	Despite its known effects in brain reward centers, nicotine can be aversive in high doses. Here, the authors show that nicotine aversion depends on low-affinity nicotinic acetylcholine receptors expressed on projections from the interpeduncular nucleus to the laterodorsal tegmentum.
format	article
author	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
author_facet	Shannon L. Wolfman Daniel F. Gill Fili Bogdanic Katie Long Ream Al-Hasani Jordan G. McCall Michael R. Bruchas Daniel S. McGehee
author_sort	Shannon L. Wolfman
title	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_short	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_fullStr	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_full_unstemmed	Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum
title_sort	nicotine aversion is mediated by gabaergic interpeduncular nucleus inputs to laterodorsal tegmentum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e15d944c114d4cb58850d8356381d660
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Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum

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