Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men

BackgroundAs arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coro...

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Autores principales:	Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Keisei Kosaki, Nobuhiko Akazawa, Zempo‐Miyaki Asako, Takehiko Tsujimoto, Tetsuhiro Kidokoro, Kiyoji Tanaka, Seiji Maeda
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	arterial stiffness erectile dysfunction predictors sexual dysfunction vascular function Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e165612e853a4853a62ad38b8cae38e7
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spelling	oai:doaj.org-article:e165612e853a4853a62ad38b8cae38e72021-11-12T17:00:20ZSexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men10.1161/JAHA.117.0079642047-9980https://doaj.org/article/e165612e853a4853a62ad38b8cae38e72018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.007964https://doaj.org/toc/2047-9980BackgroundAs arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross‐sectional study. Methods and ResultsCarotid‐femoral pulse wave velocity (PWV), brachial‐ankle PWV, femoral‐ankle PWV, and arterial stiffness gradient (PWV ratio: carotid‐femoral PWV/femoral‐ankle PWV) were measured as indexes of central, systemic, and peripheral arterial stiffness and peripheral organ damage, respectively, in 317 adult men. In addition, erectile function was assessed by using the questionnaire International Index of Erectile Function 5 (a descending score indicates worsening of erectile function). The scores of male sexual function were inversely correlated with carotid‐femoral PWV (rs=−0.41), brachial‐ankle PWV (rs=−0.35), femoral‐ankle PWV (rs=−0.19), and PWV ratio (rs=−0.33). Furthermore, multivariate linear regression analyses revealed that International Index of Erectile Function 5 scores were significantly associated with carotid‐femoral PWV (β=−0.22) and PWV ratio (β=−0.25), but not with brachial‐ankle PWV and femoral‐ankle PWV. ConclusionsOur results indicated that erectile function is independently associated with central arterial stiffness and peripheral organ damage. These findings suggest that male sexual function could be an easily identifiable and independent marker of increased central arterial stiffness and peripheral organ damage.Hiroshi KumagaiToru YoshikawaKanae MyoenzonoKeisei KosakiNobuhiko AkazawaZempo‐Miyaki AsakoTakehiko TsujimotoTetsuhiro KidokoroKiyoji TanakaSeiji MaedaWileyarticlearterial stiffnesserectile dysfunctionpredictorssexual dysfunctionvascular functionDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial stiffness erectile dysfunction predictors sexual dysfunction vascular function Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	arterial stiffness erectile dysfunction predictors sexual dysfunction vascular function Diseases of the circulatory (Cardiovascular) system RC666-701 Hiroshi Kumagai Toru Yoshikawa Kanae Myoenzono Keisei Kosaki Nobuhiko Akazawa Zempo‐Miyaki Asako Takehiko Tsujimoto Tetsuhiro Kidokoro Kiyoji Tanaka Seiji Maeda Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
description	BackgroundAs arterial stiffness increases in the absence of subjective symptoms, a personal indicator that reflects increased risk of cardiovascular disease is necessary. Penile erection is regulated by vascular function, and atherosclerosis affects the penile artery earlier than it affects the coronary and carotid arteries. Therefore, we hypothesized that deterioration of erectile function could be a marker of increased risk for cardiovascular disease. To test our hypothesis, we assessed erectile function and arterial stiffness in a cross‐sectional study. Methods and ResultsCarotid‐femoral pulse wave velocity (PWV), brachial‐ankle PWV, femoral‐ankle PWV, and arterial stiffness gradient (PWV ratio: carotid‐femoral PWV/femoral‐ankle PWV) were measured as indexes of central, systemic, and peripheral arterial stiffness and peripheral organ damage, respectively, in 317 adult men. In addition, erectile function was assessed by using the questionnaire International Index of Erectile Function 5 (a descending score indicates worsening of erectile function). The scores of male sexual function were inversely correlated with carotid‐femoral PWV (rs=−0.41), brachial‐ankle PWV (rs=−0.35), femoral‐ankle PWV (rs=−0.19), and PWV ratio (rs=−0.33). Furthermore, multivariate linear regression analyses revealed that International Index of Erectile Function 5 scores were significantly associated with carotid‐femoral PWV (β=−0.22) and PWV ratio (β=−0.25), but not with brachial‐ankle PWV and femoral‐ankle PWV. ConclusionsOur results indicated that erectile function is independently associated with central arterial stiffness and peripheral organ damage. These findings suggest that male sexual function could be an easily identifiable and independent marker of increased central arterial stiffness and peripheral organ damage.
format	article
author	Hiroshi Kumagai Toru Yoshikawa Kanae Myoenzono Keisei Kosaki Nobuhiko Akazawa Zempo‐Miyaki Asako Takehiko Tsujimoto Tetsuhiro Kidokoro Kiyoji Tanaka Seiji Maeda
author_facet	Hiroshi Kumagai Toru Yoshikawa Kanae Myoenzono Keisei Kosaki Nobuhiko Akazawa Zempo‐Miyaki Asako Takehiko Tsujimoto Tetsuhiro Kidokoro Kiyoji Tanaka Seiji Maeda
author_sort	Hiroshi Kumagai
title	Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
title_short	Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
title_full	Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
title_fullStr	Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
title_full_unstemmed	Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men
title_sort	sexual function is an indicator of central arterial stiffness and arterial stiffness gradient in japanese adult men
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/e165612e853a4853a62ad38b8cae38e7
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Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men

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