Quantitative nanoscale MRI with a wide field of view

Abstract Novel magnetic sensing modalities using quantum sensors or nanoscale probes have drastically improved the sensitivity and hence spatial resolution of nuclear magnetic resonance imaging (MRI) down to the nanoscale. Recent demonstrations of nuclear magnetic resonance (NMR) with paramagnetic c...

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Autores principales:	F. Ziem, M. Garsi, H. Fedder, J. Wrachtrup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1664834f88f4c7eb799ad84032d59a7
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spelling	oai:doaj.org-article:e1664834f88f4c7eb799ad84032d59a72021-12-02T15:09:47ZQuantitative nanoscale MRI with a wide field of view10.1038/s41598-019-47084-w2045-2322https://doaj.org/article/e1664834f88f4c7eb799ad84032d59a72019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47084-whttps://doaj.org/toc/2045-2322Abstract Novel magnetic sensing modalities using quantum sensors or nanoscale probes have drastically improved the sensitivity and hence spatial resolution of nuclear magnetic resonance imaging (MRI) down to the nanoscale. Recent demonstrations of nuclear magnetic resonance (NMR) with paramagnetic colour centres include single molecule sensitivity, and sub-part-per-million spectral resolution. Mostly, these results have been obtained using well-characterised single sensors, which only permit extended imaging by scanning-probe microscopy. Here, we enhance multiplexed MRI with a thin layer of ensemble spin sensors in an inhomogeneous control field by optimal control spin manipulation to improve ensemble sensitivity and field of view (FOV). We demonstrate MRI of fluorine in patterned thin films only 1.2 nm in thickness, corresponding to a net moment of 120 nuclear spins per sensor spin. With the aid of the NMR signal, we reconstruct the nanoscale depth distribution of the sensor spins within the substrate. In addition, we exploit inhomogeneous ensemble control to squeeze the point spread function of the imager to about 100 nm and show that localisation of a point-like NMR signal within 40 nm is feasible. These results pave the way to quantitive NMR ensemble sensing and magnetic resonance microscopy with a resolution of few ten nanometers.F. ZiemM. GarsiH. FedderJ. WrachtrupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Ziem M. Garsi H. Fedder J. Wrachtrup Quantitative nanoscale MRI with a wide field of view
description	Abstract Novel magnetic sensing modalities using quantum sensors or nanoscale probes have drastically improved the sensitivity and hence spatial resolution of nuclear magnetic resonance imaging (MRI) down to the nanoscale. Recent demonstrations of nuclear magnetic resonance (NMR) with paramagnetic colour centres include single molecule sensitivity, and sub-part-per-million spectral resolution. Mostly, these results have been obtained using well-characterised single sensors, which only permit extended imaging by scanning-probe microscopy. Here, we enhance multiplexed MRI with a thin layer of ensemble spin sensors in an inhomogeneous control field by optimal control spin manipulation to improve ensemble sensitivity and field of view (FOV). We demonstrate MRI of fluorine in patterned thin films only 1.2 nm in thickness, corresponding to a net moment of 120 nuclear spins per sensor spin. With the aid of the NMR signal, we reconstruct the nanoscale depth distribution of the sensor spins within the substrate. In addition, we exploit inhomogeneous ensemble control to squeeze the point spread function of the imager to about 100 nm and show that localisation of a point-like NMR signal within 40 nm is feasible. These results pave the way to quantitive NMR ensemble sensing and magnetic resonance microscopy with a resolution of few ten nanometers.
format	article
author	F. Ziem M. Garsi H. Fedder J. Wrachtrup
author_facet	F. Ziem M. Garsi H. Fedder J. Wrachtrup
author_sort	F. Ziem
title	Quantitative nanoscale MRI with a wide field of view
title_short	Quantitative nanoscale MRI with a wide field of view
title_full	Quantitative nanoscale MRI with a wide field of view
title_fullStr	Quantitative nanoscale MRI with a wide field of view
title_full_unstemmed	Quantitative nanoscale MRI with a wide field of view
title_sort	quantitative nanoscale mri with a wide field of view
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1664834f88f4c7eb799ad84032d59a7
work_keys_str_mv	AT fziem quantitativenanoscalemriwithawidefieldofview AT mgarsi quantitativenanoscalemriwithawidefieldofview AT hfedder quantitativenanoscalemriwithawidefieldofview AT jwrachtrup quantitativenanoscalemriwithawidefieldofview
_version_	1718387785301229568

Quantitative nanoscale MRI with a wide field of view

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