Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma

Abstract Iris melanoma is a rare form of uveal melanoma with potential metastic spread. Treatment options include surgical resection, enucleation or irradiation. We analysed visual outcome, complication appearance and management in eight patients with iris melanoma following robotic-assisted CyberKn...

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Autores principales:	Valerie Schmelter, Sarah Heidorn, Alexander Muacevic, Siegfried G. Priglinger, Paul Foerster, Raffael Liegl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e167f958b78a4d7e9e17836f0ebcad5a
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spelling	oai:doaj.org-article:e167f958b78a4d7e9e17836f0ebcad5a2021-12-02T15:53:03ZRobotic assisted CyberKnife radiosurgery for the treatment of iris melanoma10.1038/s41598-021-84290-x2045-2322https://doaj.org/article/e167f958b78a4d7e9e17836f0ebcad5a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84290-xhttps://doaj.org/toc/2045-2322Abstract Iris melanoma is a rare form of uveal melanoma with potential metastic spread. Treatment options include surgical resection, enucleation or irradiation. We analysed visual outcome, complication appearance and management in eight patients with iris melanoma following robotic-assisted CyberKnife treatment. Consecutive patients from the Department of Ophthalmology at University of Munich were included in the study if they had an iris melanoma that was treated with CyberKnife and had a minimum follow-up of 12 months. We evaluated tumor thickness, largest diameter, visual acuity and complications. 8 patients were included in this report. The median age was 74 years (range: 53–86 years). The median follow-up was 23 months (range 12–48 months). Tumor thickness decreased from 2.1 to 1.4 mm on average. Four out of eight patients showed stable or increased visual acuity compared to visual acuity at first visit. We did not find a correlation of applied radiation volume or radiation dose on visual outcome. Radiation keratopathy was the most common complication in five patients. No recurrences were noted. Robotic-assisted radiosurgery following CyberKnife is a promising non-invasive, single session treatment option for iris melanoma with comparable results regarding recurrence rate or complications to brachytherapy and proton beam therapy. All included patients showed good visual outcome.Valerie SchmelterSarah HeidornAlexander MuacevicSiegfried G. PriglingerPaul FoersterRaffael LieglNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valerie Schmelter Sarah Heidorn Alexander Muacevic Siegfried G. Priglinger Paul Foerster Raffael Liegl Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
description	Abstract Iris melanoma is a rare form of uveal melanoma with potential metastic spread. Treatment options include surgical resection, enucleation or irradiation. We analysed visual outcome, complication appearance and management in eight patients with iris melanoma following robotic-assisted CyberKnife treatment. Consecutive patients from the Department of Ophthalmology at University of Munich were included in the study if they had an iris melanoma that was treated with CyberKnife and had a minimum follow-up of 12 months. We evaluated tumor thickness, largest diameter, visual acuity and complications. 8 patients were included in this report. The median age was 74 years (range: 53–86 years). The median follow-up was 23 months (range 12–48 months). Tumor thickness decreased from 2.1 to 1.4 mm on average. Four out of eight patients showed stable or increased visual acuity compared to visual acuity at first visit. We did not find a correlation of applied radiation volume or radiation dose on visual outcome. Radiation keratopathy was the most common complication in five patients. No recurrences were noted. Robotic-assisted radiosurgery following CyberKnife is a promising non-invasive, single session treatment option for iris melanoma with comparable results regarding recurrence rate or complications to brachytherapy and proton beam therapy. All included patients showed good visual outcome.
format	article
author	Valerie Schmelter Sarah Heidorn Alexander Muacevic Siegfried G. Priglinger Paul Foerster Raffael Liegl
author_facet	Valerie Schmelter Sarah Heidorn Alexander Muacevic Siegfried G. Priglinger Paul Foerster Raffael Liegl
author_sort	Valerie Schmelter
title	Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
title_short	Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
title_full	Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
title_fullStr	Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
title_full_unstemmed	Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma
title_sort	robotic assisted cyberknife radiosurgery for the treatment of iris melanoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e167f958b78a4d7e9e17836f0ebcad5a
work_keys_str_mv	AT valerieschmelter roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma AT sarahheidorn roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma AT alexandermuacevic roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma AT siegfriedgpriglinger roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma AT paulfoerster roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma AT raffaelliegl roboticassistedcyberkniferadiosurgeryforthetreatmentofirismelanoma
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Robotic assisted CyberKnife radiosurgery for the treatment of iris melanoma

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