APOPTOSIS AND INFECTIOUS DISEASES

Apoptosis as immunomodulating form of cell death plays a stabilizing role in maintaining optimal number of cells in an organism. The biological essence of cell death in infectious diseases is poorly reflected, and the concept of negative and positive values of apoptosis in the pathogenesis of diseas...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. M. Somova, N. N. Besednova, N. G. Plekhova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2015
Materias:	apoptosis infectious diseases immune system neutrophils macrophages lymphocytes Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e16bf1c74f2c4dc4ab99a19974fb52d1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e16bf1c74f2c4dc4ab99a19974fb52d1
record_format	dspace
spelling	oai:doaj.org-article:e16bf1c74f2c4dc4ab99a19974fb52d12021-11-22T07:09:47ZAPOPTOSIS AND INFECTIOUS DISEASES2220-76192313-739810.15789/2220-7619-2014-4-303-318https://doaj.org/article/e16bf1c74f2c4dc4ab99a19974fb52d12015-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/241https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Apoptosis as immunomodulating form of cell death plays a stabilizing role in maintaining optimal number of cells in an organism. The biological essence of cell death in infectious diseases is poorly reflected, and the concept of negative and positive values of apoptosis in the pathogenesis of diseases is presented ambiguously. The review focuses on the classical caspase-dependent apoptosis of innate and adaptive immunity cells, whose reactivity is associated with the initiation of infectious processes. Some causative agents of bacterial and viral infections can be triggers or inhibitors of apoptosis in a eukaryotic host cell, avoiding the factors of the immune system. In severe infectious diseases that occur with the development of sepsis, a fatal importance has the massive apoptotic loss of lymphocytes expressed lymphocyte apoptosis that leads to immunodeficiency states and the majority of patients corresponds to premortem decrease in circulating lymphocytes. Further studies on the identification of the molecular elements whereby pathogenic agents cause the cell death effort to develop new therapeutic approaches, including inhibition of apoptosis, to prevent the progression of severe courses of infections.L. M. SomovaN. N. BesednovaN. G. PlekhovaSankt-Peterburg : NIIÈM imeni Pasteraarticleapoptosisinfectious diseasesimmune systemneutrophilsmacrophageslymphocytesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 4, Pp 303-318 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	apoptosis infectious diseases immune system neutrophils macrophages lymphocytes Infectious and parasitic diseases RC109-216
spellingShingle	apoptosis infectious diseases immune system neutrophils macrophages lymphocytes Infectious and parasitic diseases RC109-216 L. M. Somova N. N. Besednova N. G. Plekhova APOPTOSIS AND INFECTIOUS DISEASES
description	Apoptosis as immunomodulating form of cell death plays a stabilizing role in maintaining optimal number of cells in an organism. The biological essence of cell death in infectious diseases is poorly reflected, and the concept of negative and positive values of apoptosis in the pathogenesis of diseases is presented ambiguously. The review focuses on the classical caspase-dependent apoptosis of innate and adaptive immunity cells, whose reactivity is associated with the initiation of infectious processes. Some causative agents of bacterial and viral infections can be triggers or inhibitors of apoptosis in a eukaryotic host cell, avoiding the factors of the immune system. In severe infectious diseases that occur with the development of sepsis, a fatal importance has the massive apoptotic loss of lymphocytes expressed lymphocyte apoptosis that leads to immunodeficiency states and the majority of patients corresponds to premortem decrease in circulating lymphocytes. Further studies on the identification of the molecular elements whereby pathogenic agents cause the cell death effort to develop new therapeutic approaches, including inhibition of apoptosis, to prevent the progression of severe courses of infections.
format	article
author	L. M. Somova N. N. Besednova N. G. Plekhova
author_facet	L. M. Somova N. N. Besednova N. G. Plekhova
author_sort	L. M. Somova
title	APOPTOSIS AND INFECTIOUS DISEASES
title_short	APOPTOSIS AND INFECTIOUS DISEASES
title_full	APOPTOSIS AND INFECTIOUS DISEASES
title_fullStr	APOPTOSIS AND INFECTIOUS DISEASES
title_full_unstemmed	APOPTOSIS AND INFECTIOUS DISEASES
title_sort	apoptosis and infectious diseases
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2015
url	https://doaj.org/article/e16bf1c74f2c4dc4ab99a19974fb52d1
work_keys_str_mv	AT lmsomova apoptosisandinfectiousdiseases AT nnbesednova apoptosisandinfectiousdiseases AT ngplekhova apoptosisandinfectiousdiseases
_version_	1718418075572764672

APOPTOSIS AND INFECTIOUS DISEASES

Ejemplares similares