Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs

One of the reasons that most multicellular animals survive and thrive is because of the adaptable and plastic nature of their nervous systems. For an organism to survive, it is essential for the animal to respond and adapt to environmental changes. This is achieved by sensing external cues and trans...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Umer Saleem Bhat, Navneet Shahi, Siju Surendran, Kavita Babu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neuropeptides C. elegans locomotion behavior signaling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e16dab2242b34159b8a541841a781d06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e16dab2242b34159b8a541841a781d06
record_format	dspace
spelling	oai:doaj.org-article:e16dab2242b34159b8a541841a781d062021-12-02T09:32:56ZNeuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs1662-509910.3389/fnmol.2021.786471https://doaj.org/article/e16dab2242b34159b8a541841a781d062021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.786471/fullhttps://doaj.org/toc/1662-5099One of the reasons that most multicellular animals survive and thrive is because of the adaptable and plastic nature of their nervous systems. For an organism to survive, it is essential for the animal to respond and adapt to environmental changes. This is achieved by sensing external cues and translating them into behaviors through changes in synaptic activity. The nervous system plays a crucial role in constantly evaluating environmental cues and allowing for behavioral plasticity in the organism. Multiple neurotransmitters and neuropeptides have been implicated as key players for integrating sensory information to produce the desired output. Because of its simple nervous system and well-established neuronal connectome, C. elegans acts as an excellent model to understand the mechanisms underlying behavioral plasticity. Here, we critically review how neuropeptides modulate a wide range of behaviors by allowing for changes in neuronal and synaptic signaling. This review will have a specific focus on feeding, mating, sleep, addiction, learning and locomotory behaviors in C. elegans. With a view to understand evolutionary relationships, we explore the functions and associated pathophysiology of C. elegans neuropeptides that are conserved across different phyla. Further, we discuss the mechanisms of neuropeptidergic signaling and how these signals are regulated in different behaviors. Finally, we attempt to provide insight into developing potential therapeutics for neuropeptide-related disorders.Umer Saleem BhatUmer Saleem BhatNavneet ShahiSiju SurendranKavita BabuFrontiers Media S.A.articleneuropeptidesC. eleganslocomotionbehaviorsignalingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropeptides C. elegans locomotion behavior signaling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neuropeptides C. elegans locomotion behavior signaling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Umer Saleem Bhat Umer Saleem Bhat Navneet Shahi Siju Surendran Kavita Babu Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
description	One of the reasons that most multicellular animals survive and thrive is because of the adaptable and plastic nature of their nervous systems. For an organism to survive, it is essential for the animal to respond and adapt to environmental changes. This is achieved by sensing external cues and translating them into behaviors through changes in synaptic activity. The nervous system plays a crucial role in constantly evaluating environmental cues and allowing for behavioral plasticity in the organism. Multiple neurotransmitters and neuropeptides have been implicated as key players for integrating sensory information to produce the desired output. Because of its simple nervous system and well-established neuronal connectome, C. elegans acts as an excellent model to understand the mechanisms underlying behavioral plasticity. Here, we critically review how neuropeptides modulate a wide range of behaviors by allowing for changes in neuronal and synaptic signaling. This review will have a specific focus on feeding, mating, sleep, addiction, learning and locomotory behaviors in C. elegans. With a view to understand evolutionary relationships, we explore the functions and associated pathophysiology of C. elegans neuropeptides that are conserved across different phyla. Further, we discuss the mechanisms of neuropeptidergic signaling and how these signals are regulated in different behaviors. Finally, we attempt to provide insight into developing potential therapeutics for neuropeptide-related disorders.
format	article
author	Umer Saleem Bhat Umer Saleem Bhat Navneet Shahi Siju Surendran Kavita Babu
author_facet	Umer Saleem Bhat Umer Saleem Bhat Navneet Shahi Siju Surendran Kavita Babu
author_sort	Umer Saleem Bhat
title	Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
title_short	Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
title_full	Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
title_fullStr	Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
title_full_unstemmed	Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs
title_sort	neuropeptides and behaviors: how small peptides regulate nervous system function and behavioral outputs
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e16dab2242b34159b8a541841a781d06
work_keys_str_mv	AT umersaleembhat neuropeptidesandbehaviorshowsmallpeptidesregulatenervoussystemfunctionandbehavioraloutputs AT umersaleembhat neuropeptidesandbehaviorshowsmallpeptidesregulatenervoussystemfunctionandbehavioraloutputs AT navneetshahi neuropeptidesandbehaviorshowsmallpeptidesregulatenervoussystemfunctionandbehavioraloutputs AT sijusurendran neuropeptidesandbehaviorshowsmallpeptidesregulatenervoussystemfunctionandbehavioraloutputs AT kavitababu neuropeptidesandbehaviorshowsmallpeptidesregulatenervoussystemfunctionandbehavioraloutputs
_version_	1718398094797701120

Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs

Ejemplares similares